602-05A
Hair Follicle Dermal Papilla Cells: HFDPC, adult
Synonyma:
HFDPC, HFDPC cells
About This Item
Doporučené produkty
biological source
human scalp (hair follicle papilla)
packaging
pkg of 500,000 cells
manufacturer/tradename
Cell Applications, Inc
growth mode
Adherent
morphology
mesenchymal
technique(s)
cell culture | mammalian: suitable
relevant disease(s)
Alzheimer′s disease
shipped in
dry ice
storage temp.
−196°C
General description
Human Hair Follicle Dermal Papilla Cells (HFDPC) are mesenchymal cells isolated from the hair papilla of normal human scalp hair follicles. Hair papilla, in the adult hair follicle, plays a crucial role in the dermal-epidermal interactions that control hair production and events of the hair growth cycle. HFDPC can therefore be used for studying cellular mechanisms organizing the hair follicle, and for the development and evaluation of hair growth products.
HFDPC have been used to demonstrate that IL-1α affects dermal papilla activity by decreasing androgen receptor expression and stimulating secretion of KFG, VEGF, IL-8 and GM-CSF (Boivin, 2006). They were also used to investigate how gene expression and cell proliferation are affected by testosterone analogues (Reiter, 2008), potential hair growth enhancing agents (Sasajima, 2008) and microbial metabolites (Takigawa, 2012). Using HFDPC, along with Human Epidermal Keratinocytes and Human Bronchial Epithelial Cells, scientists also studied mechanisms of cellular senescence, and develop ed methodology to extend cellular life span and immortalize the cells by inhibiting p16INK4a and introducing hTERT (Haga, 2007). Finally, HFDPC have been used to discover the link between the androgen-induced alopecia and circadian rhythms, mediated by a “clock gene” transcription factor BMAL1 (Watabe, 2013).
Cell Line Origin
Application
Components
Preparation Note
- 2nd passage, >500,000 cells in Cell Basal Medium containing 20% FBS & 5% DMSO
- Can be cultured at least 6 doublings
Subculture Routine
Disclaimer
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Vyberte jednu z posledních verzí:
Osvědčení o analýze (COA)
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Dokumenty section.
Potřebujete-li pomoc, obraťte se na Zákaznická podpora
Již tento produkt vlastníte?
Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.
Zákazníci si také prohlíželi
Protokoly
Technical information for working with human follicle dermal papilla cells including thawing, subculturing and cryopreservation.
Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..
Obraťte se na technický servis.