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Key Documents

30290

Sigma-Aldrich

Cytidine 5′-diphosphocholine sodium salt hydrate

≥99.0% (HPLC)

Synonyma:

CDP-choline-Na

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About This Item

Empirický vzorec (Hillův zápis):
C14H25N4NaO11P2 · xH2O
Číslo CAS:
33818-15-4
Molekulová hmotnost:
510.31 (anhydrous basis)
Beilstein/REAXYS Number:
4110040
MDL number:
MFCD00150508
UNSPSC Code:
41106305
PubChem Substance ID:
57648419
NACRES:
NA.51

biological source

synthetic

assay

≥99.0% (HPLC)

form

powder

impurities

≤8% water

storage temp.

2-8°C

SMILES string

[Na+].C[N+](C)(C)CCOP([O-])(=O)OP([O-])(=O)OCC1OC([C@H](O)[C@@H]1O)N2C=CC(N)=NC2=O

InChI

1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9?,11-,12-,13?;/m1./s1

InChI key

YWAFNFGRBBBSPD-MBWJOHGMSA-M

Application

Cytidine 5′-diphosphocholine (CDP-choline) is generated by choline-phosphate cytidylyltransferase EC 2.7.7.15 in support of the synthesis of phosphatidylcholine. CDP-choline is being used in studies of its affects on neurorecovery.
Cytidine 5′-diphosphocholine sodium salt hydrate has been used as a component of the mixture during the ribonucleotide reductase (RNR) assay in mouse primary pancreatic acinar cells.

Biochem/physiol Actions

Cytidine 5′-diphosphocholine (CDP-choline) is an endogenous compound that plays an important role in the synthesis of phospholipids in the cell membrane. It acts as a choline donor for the biosynthesis of acetylcholine and phosphatidylcholine, a neuronal membrane phospholipid. CDP-choline enhances brain metabolism and influences the levels of various neurotransmitters including dopamine, epinephrine, and acetylcholine. It has been studied as a neuroprotectant after cerebral ischemia. CDP-choline is observed to exhibit therapeutic effects against cognitive impairment arising from multiple causes, cerebral vascular diseases, after-head trauma, and Alzheimer′s disease.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Sigma-Aldrich

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Sigma-Aldrich

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Deniz Bagdas et al.
Behavioural pharmacology, 22(5-6), 589-598 (2011-08-13)
This study was designed to test the effects of intracerebroventricularly (i.c.v.) administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain. The i.c.v. administration of CDP-choline (0.5, 1.0 and 2.0 µmol) produced a dose and
Patricia M Arenth et al.
PM & R : the journal of injury, function, and rehabilitation, 3(6 Suppl 1), S123-S131 (2011-07-08)
Cytidine 5'-diphosphocholine (CDP-choline or citicoline) is a highly bioavailable compound with potential benefits for aiding neural repair and increasing acetylcholine levels in the central and peripheral nervous system. As a result, many researchers have investigated the use of CDP-choline for
Erhan Aslan et al.
Neurological research, 33(7), 766-773 (2011-07-16)
Topical cytidine-5'-diphosphocholine (CDP-choline) has been shown to improve the functional recovery and promote the nerve regeneration of injured sciatic nerves in rats. The aims of this study were to test whether CDP-choline was effective at promoting nerve healing when the
Tomás Sobrino et al.
Neurological research, 33(6), 572-577 (2011-06-29)
The increase in circulating endothelial progenitor cells (EPCs) is associated with a better outcome in patients with acute ischemic stroke. CDP-choline (citicoline) increases brain plasticity after experimental stroke. Therefore, we study if citicoline treatment could increase the EPC concentration after
Lorissa J Niebergall et al.
Biochimica et biophysica acta, 1811(12), 1177-1185 (2011-07-13)
Several studies suggest that low levels of hepatic phosphatidylcholine (PC) play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis. Liver-specific elimination of CTα

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