BP578

Dexamethasone

British Pharmacopoeia (BP) Assay Standard

• Synonyma: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
• Empirický vzorec (Hillův zápis): C₂₂H₂₉FO₅
• Číslo CAS: 50-02-2
• Molekulová hmotnost: 392.46
• EC Number: 200-003-9
• UNSPSC Code: 41116107
• NACRES: NA.24
• Beilstein/REAXYS Number: 2066651
• MDL number: MFCD00064136

Vlastnosti

• grade: pharmaceutical primary standard
• API family: dexamethasone
• form: solid
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: BP
• mp: 262-264 °C (lit.)
• application(s): pharmaceutical; pharmaceutical small molecule
• format: neat
• storage temp.: 2-8°C
• SMILES string: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
• InChI key: UREBDLICKHMUKA-CXSFZGCWSA-N
• Gene Information: human ... NR3C1(2908)

Popis

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Tobramycin and Dexamethasone Eye Drops, Suspension

Dexamethasone Sodium Phosphate Oral Solution

Hydrocortisone Sodium Succinate Injection

Prednisolone Tablets

Dexamethasone Eye Drops, Suspension

Dexamethasone Sodium Phosphate Eye Drops, Solution

Dexamethasone and Neomycin Ear Spray

Betamethasone Tablets

Dexamethasone Tablets

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Glucocorticoid anti-inflammatory agent

Other Notes

Sales restrictions may apply.

Bezpečnostní informace

• pictograms: GHS08
• signalword: Danger
• hcodes: H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable