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Key Documents

MAB1999

Sigma-Aldrich

Anti-Integrin α5β1 Antibody, clone HA5

clone HA5, Chemicon®, from mouse

Synonyma:

VLA-5

Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

HA5, monoclonal

species reactivity

pig, human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable
immunoprecipitation (IP): suitable

isotype

IgG2bκ

NCBI accession no.

NM_002205.2

UniProt accession no.

P08648

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGA5(3678)

Související kategorie

Specificity

Reacts with the fibronectin receptor VLA-5 (alpha-5beta-1) integrin complex.

Application

Anti-Integrin α5β1 Antibody, clone HA5 detects level of Integrin α5β1 & has been published & validated for use in FC & IP.
Immunoprecipitation of VLA-5 integrins from lysate of 10E6 cell equivalent requires 2 μg of MAB1999.

Flow cytometry: 10 μg/mL

Does not detect VLA-5 by Western blot.

MAB1999 does not affect VLA-5 mediated cell adhesion to fibronectin.

Optimal working dilutions must be determined by end user.

Physical form

Format: Purified
Purified immunoglobulin from Protein A chromatography. Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl, 0.1% sodium azide.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Navštívit knihovnu dokumentů

Ingrid Burvenich et al.
Molecular cancer therapeutics, 7(12), 3771-3779 (2008-12-17)
This study identifies and characterizes the antigen recognized by monoclonal antibody (mAb) 14C5. We compared the expression of antigen 14C5 with the expression of eight integrin subunits (alpha1, alpha2, alpha3, alphav, beta1, beta2, beta3, and beta4) and three integrin heterodimers
Yuya Sato et al.
The Journal of biological chemistry, 284(18), 11873-11881 (2009-03-12)
Recently we reported that N-glycans on the beta-propeller domain of the integrin alpha5 subunit (S-3,4,5) are essential for alpha5beta1 heterodimerization, expression, and cell adhesion. Herein to further investigate which N-glycosylation site is the most important for the biological function and
Qinglei Hang et al.
The Journal of biological chemistry, 290(49), 29345-29360 (2015-10-21)
Integrin α5β1-mediated cell adhesion regulates a multitude of cellular responses, including cell proliferation, survival, and cross-talk between different cellular signaling pathways. Integrin α5β1 is known to convey permissive signals enabling anchorage-dependent receptor tyrosine kinase signaling. However, the effects of integrin
Paul Day et al.
International journal of oncology, 39(4), 863-871 (2011-07-02)
Integrins, a family of heterodimeric receptors for cell adhesion to the extracellular matrix (ECM), play key roles in cell migration, cancer progression and metastasis. As transmembrane proteins, integrins are transported in vesicles and delivered to the cell surface by vesicular
Elisabetta Vergani et al.
Oncotarget, 7(4), 4428-4441 (2015-12-20)
In melanoma, the adaptative cell response to BRAF inhibitors includes altered patterns of cytokine production contributing to tumor progression and drug resistance. Among the factors produced by PLX4032-resistant melanoma cell lines, CCL2 was higher compared to the sensitive parental cell
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