ABN1698
Anti-Aspa/Nur7 Antibody
from rabbit, purified by affinity chromatography
Synonyma:
Aspartoacylase, Aminoacylase-2, ACY-2, Aspa/Nur7, Anti-Aspartoacylase
Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Doporučené produkty
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, rat
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ASPA(443)
General description
Aspartoacylase (EC 3.5.1.15; UniProt Q8R3P0; also known as Acy-2, Aminoacylase-2, Nur-7) is encoded by the Aspa (also known as Acy2) gene (Gene ID 11484) in murine species. Aspartoacylase catalyzes the deacetylation of N-acetylaspartate (NAA) to generate free acetate in the central nervous system (CNS). Mutations in the ASPA gene cause the autosomal recessive neurodegenerative Canavan disease (CD) that results in inadequate lipid/myelin synthesis during development. Immunohistochemical staining reveals that aspartoacylase colocalizes with the oligodendrocyte marker CC1 throughout the brain, indicating its role in myelination.
Immunogen
N-terminally his-tagged full-length recombinant mouse Aspa/Nur7.
Application
Immunohistochemistry Analysis: A representative lot detected Aspa/Nur7-positive oligodendrocytes in corpus callosum/external capsule using free-floating mouse brain sections (Courtesy of Dr. John R. Moffett, Uniformed Services University of the Health Sciences).
Western Blotting Analysis: A representative lot detected Aspa/Nur7 in the cytosol, but not myelin, fraction from rat brain tissue homogenate (Madhavarao, C.N., et al. (2004). J Comp Neurol. 472(3):318-329).
Immunohistochemistry Analysis: A representative lot detected Aspa/Nur7 expression pattern in various regions of rat forebrain, including corpus callosum, cerebral cortex, hippocampal commissure (hc), fimbria, and anterior commissure (Madhavarao, C.N., et al. (2004). J Comp Neurol. 472(3):318-329).
Immunohistochemistry Analysis: A representative lot detected similar Aspa/Nur7 expression pattern as CC1 in various regions of rat forebrain, including the Purkinjie & axonal fiber layers of cerebellum, corpus callosum, as well as layer 2 of primary somatosensory cortex (Madhavarao, C.N., et al. (2004). J Comp Neurol. 472(3):318-329).
Western Blotting Analysis: A representative lot detected Aspa/Nur7 in the cytosol, but not myelin, fraction from rat brain tissue homogenate (Madhavarao, C.N., et al. (2004). J Comp Neurol. 472(3):318-329).
Immunohistochemistry Analysis: A representative lot detected Aspa/Nur7 expression pattern in various regions of rat forebrain, including corpus callosum, cerebral cortex, hippocampal commissure (hc), fimbria, and anterior commissure (Madhavarao, C.N., et al. (2004). J Comp Neurol. 472(3):318-329).
Immunohistochemistry Analysis: A representative lot detected similar Aspa/Nur7 expression pattern as CC1 in various regions of rat forebrain, including the Purkinjie & axonal fiber layers of cerebellum, corpus callosum, as well as layer 2 of primary somatosensory cortex (Madhavarao, C.N., et al. (2004). J Comp Neurol. 472(3):318-329).
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
This Anti-Aspa/Nur7 Antibody is validated for use in Western Blotting, Immunohistochemistry for the detection of Aspa/Nur7.
Quality
Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Aspa/Nur7 in 10 µg of rat brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Aspa/Nur7 in 10 µg of rat brain tissue lysate.
Target description
~37 kDa observed
Physical form
Protein G Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Ještě jste nenalezli správný produkt?
Vyzkoušejte náš produkt Nástroj pro výběr produktů.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Osvědčení o analýze (COA)
Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.
Již tento produkt vlastníte?
Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.
Lillian M Toomey et al.
Scientific reports, 11(1), 22594-22594 (2021-11-21)
Cuprizone is a copper-chelating agent that induces pathology similar to that within some multiple sclerosis (MS) lesions. The reliability and reproducibility of cuprizone for inducing demyelinating disease pathology depends on the animals ingesting consistent doses of cuprizone. Cuprizone-containing pelleted feed
Yun-Yun Hu et al.
Frontiers in psychiatry, 14, 1186073-1186073 (2023-07-06)
Social interaction is a fundamental human need. Social isolation (SI) can have negative effects on both emotional and cognitive function. However, it is currently unclear how age and the duration of SI affect emotion and recognition function. In addition, there
Anthony Fernández-Castañeda et al.
Cell, 185(14), 2452-2468 (2022-06-30)
COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection and found white-matter-selective microglial
Zhixin Lei et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(33), 6444-6456 (2020-07-15)
Previous studies demonstrate that activation of pancreatic ER kinase (PERK) protects oligodendrocytes against inflammation in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). Interestingly, data indicate that the cytoprotective effects of PERK activation on oligodendrocytes during EAE are
Simon Pan et al.
Nature neuroscience, 23(4), 487-499 (2020-02-12)
Experience-dependent myelination is hypothesized to shape neural circuit function and subsequent behavioral output. Using a contextual fear memory task in mice, we demonstrate that fear learning induces oligodendrocyte precursor cells to proliferate and differentiate into myelinating oligodendrocytes in the medial
Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..
Obraťte se na technický servis.