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ABE69

Sigma-Aldrich

Anti-PTIP Antibody

from chicken, purified by affinity chromatography

Synonyma:

PAX interacting (with transcription-activation domain) protein 1, PAX transactivation activation domain-interacting protein, protein encoded by CAG trinucleotide repeats, PAX transcription activation domain interacting protein 1 like

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

chicken

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse, human

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PAXIP1(22976)

General description

PAX transactivation activation domain-interacting protein (PTIP) is a ubiquitous nuclear protein composed of 5 tandem BRCA1 carboxyl-terminal (BRCT) domains. PTIP was initially identified as an interacting, transactivation protein that binds to the C-terminal end of Pax2. Since its discovery, studies have shown PTIP to bind several Pax proteins, playing a critical role in response to DNA damage. It also has activity as a phosphoserine/ phosphothreonine-specific binding module, and can discern ATM and ATR gamma irradiation induced phosphorylated substrates. PTIP is involved in early cellular development and is likely to have a role in cell proliferation as well.

Immunogen

Histidine-tagged recombinant protein corresponding to human PTIP.

Application

Anti-PTIP Antibody is a Chicken Polyclonal Antibody for detection of PTIP also known as PAX transactivation activation domain-interacting protein, protein encoded by CAG trinucleotide repeats & has been validated in WB, IHC & IF.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH (Patel, S., et al. (2007).

Immunofluorescence Analysis: A represenative lot was used by an independent laboratory in IF (Lechner, M., et al. (2000).
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology

Quality

Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected PTIP in 10 µg of A431 cell lysate.

Target description

~120 kDa observed.
Other isoforms may be observed in some lysates.

Physical form

Affinity purified
Purified chicken polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
A431 cell lysate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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