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ABC213

Anti-phospho ULK1 Antibody (Ser777)

from rabbit, purified by affinity chromatography

Synonyma:

Serine/threonine-protein kinase ULK1, Serine/threonine-protein kinase Unc51.1, Unc-51-like kinase 1

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Velikost baleníSkladová položkaDostupnostCena
100 μg

Očekávané datum odeslání14. dubna 2026odAreál Kühne+Nagel spol. s r.o.

11 800,00 Kč

O této položce

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human
Application:
WB, inhibition assay
Citations:
9

11 800,00 Kč


Očekávané datum odeslání14. dubna 2026podrobné informace


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biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

inhibition assay: suitable (peptide), western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

phosphorylation (pSer777)

General description

ULK1 or autophagy-related protein 1 homolog (ATG1) is a serine/threonine protein kinase. It is a ubiquitously expressed protein that is highly abundant in the brain, skeletal muscle, and heart. It is involved in the signaling pathway of mTOR receptors leading to the regulation of autophagy in nutrient-deprived cells. mTOR may interact with ULK1 as a complex of ULK1/FIP200/Atg13. ULK1 may play an important role in neuronal development: Elimination of ULK1′s enzymatic activity by targeted disruption of its kinase domain has blocked the outgrowth of neurons in the developing mouse brain, possibly by blocking the ULK1-mediated trafficking of neurotrophins.
~120 kDa observed

Immunogen

KLH-conjugated linear peptide corresponding to a region near the C-terminus of human ULK1 phosphorylated at Ser777.

Application

Anti-phospho ULK1 Antibody (Ser777) is a highly specific rabbit polyclonal antibody, that targets Autophagy-related protein & has been tested in western blotting & Peptide Inhibition Assay.
Evaluated by Western Blotting/Peptide Inhibition Analysis in A431 cell lysate.

Western Blotting/Peptide Inhibition Analysis: 2 µg/mL of this antibody detected phospho ULK1 (Ser777) in 10 µg of A431 cell lysate.

Analysis Note

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected phospho ULK1 (Ser777) in 10 µg of A431 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Tato položka
ABC212ABC112MABC307
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

UniProt accession no.

O70405

UniProt accession no.

O70405

UniProt accession no.

O75385

UniProt accession no.

O75385

technique(s)

inhibition assay: suitable (peptide), western blot: suitable

technique(s)

inhibition assay: suitable (peptide), western blot: suitable

technique(s)

inhibition assay: suitable (peptide), western blot: suitable

technique(s)

western blot: suitable

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

15D12.3, monoclonal


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Skladovací třída

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



Osvědčení o analýze (COA)

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Autophagy is a regulated process involved in cell growth, development, and recycling of cytoplasmic components in cells.


Jingxiang Wang et al.
Virulence, 13(1), 1697-1712 (2022-09-29)
Autophagy plays an important role in defending against invading microbes. However, numerous viruses can subvert autophagy to benefit their replication. Porcine epidemic diarrhoea virus (PEDV) is an aetiological agent that causes severe porcine epidemic diarrhoea. How PEDV infection regulates autophagy
Xiaoning Hao et al.
Experimental neurology, 363, 114358-114358 (2023-02-28)
Angelman Syndrome (AS) is a neurodevelopmental disorder caused by deficiency of the maternally expressed UBE3A gene. The UBE3A proteins functions both as an E3 ligase in the ubiquitin-proteasome system (UPS), and as a transcriptional co-activator for steroid hormone receptors. Here
Sheng Dai et al.
Autophagy, 13(8), 1435-1451 (2017-06-15)
The drug 2-hydroxypropyl-β-cyclodextrin (HPβCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease, type C (NPC) and has been advanced to human clinical trials. However, its mechanism of action for reducing cholesterol accumulation in NPC cells is uncertain and its molecular target



Globální číslo obchodní položky

Skladová položkaGTIN
ABC21304053252941191

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