677181

Vincristine Sulfate, Apocynaceae sp.

Indole alkaloid that binds to tubulin, inhibiting formation of microtubules.

• Synonyma: Vincristine Sulfate, Apocynaceae sp.
• Empirický vzorec (Hillův zápis): C₄₆H₅₆N₄O₁₀ · xH₂SO₄
• Číslo CAS: 2068-78-2
• Molekulová hmotnost: 824.96 (free base basis)
• MDL number: MFCD00084729
• UNSPSC Code: 12352210
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 20 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
• InChI key: AQTQHPDCURKLKT-JKDPCDLQSA-N

Popis

General description

Indole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Indole alkaloid that binds to tubulin, inhibiting the formulation of microtubules. Depolymerizes microtubules. Induces an increase in the micronucleus and delays cell cycle progression. Antineoplastic agent. Induces apoptosis in human lymphoma cells by distributing microtubules.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Other Notes

Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688.
Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300,H341,H361fd
• pcodes: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 2 Oral - Muta. 2 - Repr. 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable