530050-M

PRIMA-1

A cell-permeable quinuclidinone analog with antitumor properties.

• Synonyma: PRIMA-1, 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
• Empirický vzorec (Hillův zápis): C₉H₁₅NO₃
• Číslo CAS: 5608-24-2
• Molekulová hmotnost: 185.22
• MDL number: MFCD04974196
• UNSPSC Code: 12352200

Vlastnosti

• Quality Level: 100
• assay: ≥95% (NMR)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: off-white
• solubility: water: 2 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• InChI key: RFBVBRVVOPAAFS-UHFFFAOYSA-N

Popis

General description

A cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.

A cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.

Biochem/physiol Actions

Primary Target
Restores biochemical and biological function to mutant p53

Warning

Toxicity: Standard Handling (A)

Other Notes

Bykov, V.J., et al. 2002. Nat. Med.8, 282.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H334
• pcodes: P261 - P264 - P270 - P284 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Resp. Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable