345888

JMV 2959

≥97% (HPLC), powder, Ghrelin receptor antagonist, Calbiochem^®

• Synonyma: Ghrelin Receptor Antagonist, JMV 2959, Growth hormone secretagogue receptor antagonist, (R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide hydrochloride, GHSR1a Antagonist, GH secretagogue receptor antagonist, JMV2959
• Empirický vzorec (Hillův zápis): C₃₀H₃₂N₆O₂ · xHCl
• Molekulová hmotnost: 508.61 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• product name: Ghrelin Receptor Antagonist, JMV 2959,
• assay: ≥97% (HPLC)
• Quality Level: 100
• form: powder
• potency: 32 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: beige
• solubility: DMSO: 100 mg/mL; water: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Popis

General description

JMV 2959, which blocks the signaling of the growth hormone secretagogue receptor 1A, reduces the deficits in prepulse inhibition induced by the NMDAR antagonist, phencyclidine.

Application

Ghrelin Receptor Antagonist, JMV 2959 has been used to examine oxytocin receptor (OTR) and ghrelin receptor (GHSR) signaling. It has also been used as a GHS-R1a receptor antagonist to pretreat Hek cells followed by pyridone 8 exposure to study its effect on GHS-R1a receptor-mediated calcium influx.

Biochem/physiol Actions

Primary Target
Ghrelin receptor

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

Supplied as a hydrochloride salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Moulin, A., et al. 2013. Amino Acids44, 301.
Mary, S., et al. 2012. Proc Natl Acad Sci USA109, 8304.
Salome, N., et al. 2009. Eur J Pharmacol.612, 167,.
Moulin, A., et al. 2007. J Med Chem50, 579.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable