317642

Dipeptidylpeptidase IV Inhibitor IV, K579

The Dipeptidylpeptidase IV Inhibitor IV, K579, also referenced under CAS 440100-64-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyma: Dipeptidylpeptidase IV Inhibitor IV, K579, (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, DPP IV Inhibitor IV
• Empirický vzorec (Hillův zápis): C₁₇H₂₄N₆O
• Číslo CAS: 440100-64-1
• Molekulová hmotnost: 328.41
• MDL number: MFCD07364044
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white to light brown
• solubility: 1 M HCl: 16 mg/mL; DMSO: 32 mg/mL; ethanol: 6.5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: N3([C@@H](CCC3)C#N)C(=O)CNC1(CCN(CC1)c2ncccn2)C
• InChI: 1S/C17H24N6O/c1-17(21-13-15(24)23-9-2-4-14(23)12-18)5-10-22(11-6-17)16-19-7-3-8-20-16/h3,7-8,14,21H,2,4-6,9-11,13H2,1H3/t14-/m0/s1
• InChI key: JERPHRNGJBSFAP-AWEZNQCLSA-N

Popis

General description

A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC₅₀ = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration.

Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight.

Takasaki, K., et al. 2004. Eur. J. Pharmacol.505, 237.
Takasaki, K., et al. 2004. Eur. J. Pharmacol.486, 335.
Takasaki, K., et al. 2004. J. Pharmacol. Sci.95, 291.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable