238470

Cremophor^® EL

• Synonyma: Castor oil polyoxyethylene ether, Ethoxylated castor oil, PEG-35 castor oil, Polyoxyl 35 castor oil, polyoxyl 35 castor oil
• Číslo CAS: 61791-12-6
• UNSPSC Code: 12162002
• NACRES: NA.21
• MDL number: MFCD00130879

Vlastnosti

• form: liquid
• Quality Segment: 100
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: clear pale yellow
• CMC: ~0.02%
• solubility: ethanol: soluble, water: soluble, clear (at higher temperatures the solution will be come turbid)
• density: 1,050 g/cm³
• application(s): (Excipient in drug)
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: ClCC(OC(=O)N)CCl
• InChI: 1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)
• InChI key: JMNCUXPHXKHBPY-UHFFFAOYSA-N

Popis

General description

1 Set = 5 X 25 GM

A mixture of polyoxyethylated triglycerides, by reacting castor oil with ethylene oxide in a molar ratio of 1 : 35, that acts as a nonionic surfactant and serves as a formulation vehicle (p.o. and i.v. administration) for poorly-water soluble pharmacological agents.

Hydrophilic-lipophilic balance (HLB) ~ 12 - 14.

Application

• Proteomic responses of carotenoid and retinol administration to Mongolian gerbils.: This research examines the proteomic responses in Mongolian gerbils administered with carotenoids and retinol. Cremophor^® EL is utilized as a solubilizing agent for these compounds, highlighting its role in biochemical studies involving lipid-soluble substances (Bohn et al., 2018).

Packaging

Packaged under inert gas

Other Notes

Gelderblom, H., et al. 2001. Eur. J. Cancer37, 1590.

Sparreboom, A., et al. 1996. Cancer Res.56, 2112.
Woodcock, D.M., et al. 1990. Cancer Res.50, 4199.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Cremophor is a registered trademark of BASF SE

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: 494.6 °F - Not applicable
• flash_point_c: 257 °C - Not applicable