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178273

Aphidicolin

≥98% (HPLC), solid, DNA polymerase α and δ inhibitor, Calbiochem

Synonyma:

Aphidicolin

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Velikost baleníSkladová položkaDostupnostCena

O této položce

Empirický vzorec (Hillův zápis):
C20H34O4
Číslo CAS:
38966-21-1
Molekulová hmotnost:
338.48
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00083214
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
Informace o stanovených cenách a dostupnosti nejsou v současnosti dostupné.
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Název produktu

Aphidicolin, Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase.

Quality Level

100

description

Merck USA index - 14, 727

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 50 mg/mL, ethanol: soluble, methanol: soluble

shipped in

ambient

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Tato položka
17848889458376650
Aphidicolin Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase.

Sigma-Aldrich

178273

Aphidicolin

Apoptosis Inhibitor The Apoptosis Inhibitor, also referenced under CAS 54135-60-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

178488

Apoptosis Inhibitor

Aphidicolin analytical standard

Supelco

89458

Aphidicolin

D-erythro-Sphingosine, N-Hexanoyl- Biologically active, cell-permeable, non-physiological ceramide analog.

Sigma-Aldrich

376650

D-erythro-Sphingosine, N-Hexanoyl-

form

solid

form

solid

form

-

form

waxy solid

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (TLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

OK to freeze

storage condition

OK to freeze, desiccated

storage condition

-

storage condition

OK to freeze

General description

A cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3. Also available as a 30 mM solution in DMSO (Cat. No. 504744).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
DNA polymerase α, DNA polymerase δ
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Borner, M.M., et al. 1995. Cancer Res.55, 2122.
Poluha, W., et al. 1995. Oncogene 10, 185.
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci.345, 311.
Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
Hubermann, J.A. 1981. Cell23, 647.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Skladovací třída

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

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Globální číslo obchodní položky

Skladová položkaGTIN
178273-1MG04055977223163

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