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Merck

14-787-M

PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.

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Vybrat velikost

10 μG

11 400,00 Kč

250 μG

93 000,00 Kč

11 400,00 Kč

Očekávané datum odeslání18. března 2026podrobné informace

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O této položce

UNSPSC Code:
12352200
NACRES:
NA.32
eCl@ss:
32160405
Biological source:
mouse
Recombinant:
expressed in baculovirus infected Sf21 cells

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biological source

mouse

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

Mw 129 kDa (p110α; H1047R), Mw 83.6 kDa (p85α)

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_006218.2

UniProt accession no.

P42336

Quality Level

100, 300

Gene Information

mouse ... PIK3CA(18706)

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Tato položka
14-783-M14-792-M14-785-M
PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.

Sigma-Aldrich

14-787-M

PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg

PI3 Kinase (p110α(E545K)/p85α), 10 µg Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E545K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.

Sigma-Aldrich

14-783-M

PI3 Kinase (p110α(E545K)/p85α), 10 µg

PI 3-Kinase (p110α(H1047R)/p85α), 10 µg Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R & untagged, recombinant, human p85α full length.

Sigma-Aldrich

14-792-M

PI 3-Kinase (p110α(H1047R)/p85α), 10 µg

PI3 Kinase (p110α/p85α) murine, 10 µg Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α & untagged, recombinant, full length mouse p85α. Coexpressed by baculovirus in Sf21 insect cells. For use in Kinase Assays.

Sigma-Aldrich

14-785-M

PI3 Kinase (p110α/p85α) murine, 10 µg

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

technique(s)

-

technique(s)

activity assay: suitable (kinase)

Gene Information

mouse ... PIK3CA(18706)

Gene Information

human ... PIK3CA(5290)

Gene Information

human ... PIK3CA(5290)

Gene Information

mouse ... PIK3CA(18706)

biological source

mouse

biological source

human

biological source

human

biological source

mouse

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in Sf21 cells

recombinant

expressed in baculovirus infected Sf21 cells

recombinant

expressed in baculovirus infected Sf21 cells

mol wt

Mw 129 kDa (p110α; H1047R), Mw 83.6 kDa (p85α)

mol wt

Mw 125.3 kDa (p110α; E545K), Mw 83.7 kDa (p85α)

mol wt

Mw 125 kDa (p110α(H1047R)), Mw 84 kDa (p85α)

mol wt

Mw 129 kDa (p110α), Mw 83.6 kDa (p85α)

UniProt accession no.

P42336

UniProt accession no.

P42336

UniProt accession no.

P26450 (mouse), P27986, P42336 / P27986;P42337 / P26450 (mouse), P42336, P42337 (mouse), U79143

UniProt accession no.

P42336

General description

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R αand untagged, recombinant, full length mouse p85α.
Product Source: Coexpressed by baculovirus in Sf21 insect cells.
The H1047R substitution in p110α is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation.

Application

Research Category
Inflammation & Immunology

Biochem/physiol Actions

Protein Target: PI3Kα/p85α
Target Sub-Family: PI3K/PI4K

Packaging

Also available in 250μg size --call for pricing and availability and reference catalog number 14-787M when ordering the 250μg size.

Physical form

Ni2+/NTA-agarose

Preparation Note

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Skladovací třída

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Navštívit knihovnu dokumentů

High frequency of mutations of the PIK3CA gene in human cancers.
Yardena Samuels et al.
Science (New York, N.Y.), 304(5670), 554-554 (2004-03-16)

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