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Key Documents

07-681

Sigma-Aldrich

Anti-phospho-AMPK α (Thr172) Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_006251.5
NM_206907.3

UniProt accession no.

Q13131

shipped in

wet ice

target post-translational modification

phosphorylation (pThr172)

Gene Information

human ... PRKAA1(5562)

Specificity

Recognizes phospho-AMPKα.

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids surrounding phosphorylated Thr172 of human AMP-activated protein kinase alpha 2 (AMPKα2)

Application

Anti-phospho-AMPK α (Thr172) Antibody is an antibody against phospho-AMPK α (Thr172) for use in WB.

Quality

routinely evaluated by immunoblot on RIPA lysates from overnight starved HEK293 cells and partially purified rat liver AMPK

Target description

Mr 63 kDa

Physical form

Format: Purified

Analysis Note

Control
Serum starved HEK293 cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Osvědčení o analýze (COA)

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Navštívit knihovnu dokumentů

Tue L Nielsen et al.
Molecular genetics and metabolism, 123(1), 21-27 (2017-11-28)
McArdle disease (glycogen storage disease type V) is an inborn error of skeletal muscle metabolism, which affects glycogen phosphorylase (myophosphorylase) activity leading to an inability to break down glycogen. Patients with McArdle disease are exercise intolerant, as muscle glycogen-derived glucose
Mathias Fasshauer et al.
Biochimie, 86(11), 779-784 (2004-12-14)
Several adipocyte-secreted factors have been demonstrated to potentially link obesity, insulin resistance, and cardiovascular disease. Among those, adiponectin is an insulin-sensitizing and anti-inflammatory adipokine, concentrations of which are decreased in obesity-associated metabolic and vascular disorders. Recently, two adiponectin receptors (AdipoR)
B E Kemp et al.
Biochemical Society transactions, 31(Pt 1), 162-168 (2003-01-28)
The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.
Enhanced external counterpulsation improves peripheral artery function and glucose tolerance in subjects with abnormal glucose tolerance.
Martin, JS; Beck, DT; Aranda, JM; Braith, RW
Journal of Applied Physiology (1985)
AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.
Ruderman, N B, et al.
Acta Physiologica Scandinavica, 178, 435-442 (2003)
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