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Key Documents

06-1331

Sigma-Aldrich

Anti-IL-23R Antibody, cytoplasmic

from rabbit, purified by affinity chromatography

Synonyma:

interleukin 23 receptor

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse

technique(s)

ELISA: suitable
flow cytometry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_653302

UniProt accession no.

Q5VWK5

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... IL23R(149233)

General description

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor that is a subunit of the receptor for IL23A/IL23. IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. IL-23R associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3.

Specificity

This antibody recognizes the cytoplasmic domain of IL-23R.
May detect other isoforms of IL-23R (see molecular weight).

Immunogen

KLH-conjugated linear peptide corresponding to human IL-23R at and around the cytoplasmic domain.

Application

Anti-IL-23R Antibody, cytoplasmic detects level of IL-23R & has been published & validated for use in WB, IH, ELISA, FC.
Does not work for mouse in flow cytometry.
Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-23R in mouse spleen tissue.

Flow Cytometry Analysis: 2-10 µg from a previous lot detected IL-23R in human PBMCs. Does not work in mouse for flow cytometry.

ELISA: A previous lot of this antibody was tested on ELISA by an independent laboratory.

Quality

Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected IL-23R on 10 µg of Jurkat cell lysate.

Target description

~42 kDa Observed.
May detect other isoforms of IL-23R produced by alternative splicing: isoform 1 (~72 kDa), isoform 2 (~43 kDa), isoform 3 (~41 kDa), isoform 4 (~20 kDa), isoform 5 (~30 kDa), isoform 6 (~43 kDa) and isoform 7 (~26 kDa).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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