05-23-3831

BQ-123, Sodium Salt

A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (K_i = 40 nM for ETA versus K_i = 2.5 µM for ETB).

• Synonyma: BQ-123, Sodium Salt
• Empirický vzorec (Hillův zápis): C₃₁H₄₁N₆O₇ · Na
• Molekulová hmotnost: 632.68
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Popis

General description

A highly potent and selective ET_A (endothelin) receptor antagonist (K_i = 40 nM for ET_A versus 2.5 µM for ET_B).

A highly potent, selective, and competitive ET_A (endothelin) receptor antagonist (K_i = 40 nM for ET_A versus K_i = 2.5 μM for ET_B).

Biochem/physiol Actions

Cell permeable: no

Primary Target
ETA (endothelin) receptor antagonist

Product does not compete with ATP.

Reversible: no

Target K_i: 40 nM for ETA versus 2.5 µM for ETB

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp, Na)

Physical form

Supplied as a sodium salt. Sold on the basis of peptide content.

Other Notes

Nambi, P., et al. 1996. J. Pharmacol. Exp. Ther.277, 1567.
Bax, W.A., and Saxena, P.R. 1994. Trends Pharmacol. Sci. 15, 379.
Ihara, M., et al. 1991. Biochem. Biophys. Res. Commun. 178, 132.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable