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H-004

Supelco

Hydromorphone solution

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirický vzorec (Hillův zápis):
C17H19NO3
Číslo CAS:
466-99-9
Molekulová hmotnost:
285.34
EC Number:
200-659-6
MDL number:
MFCD00864214
UNSPSC Code:
41116107
PubChem Substance ID:
329815100
NACRES:
NA.24

grade

certified reference material

form

liquid

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

CN1CC[C@@]23[C@H]4CCC(=O)[C@@H]2Oc5c(O)ccc(C[C@@H]14)c35

InChI

1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1

InChI key

WVLOADHCBXTIJK-YNHQPCIGSA-N

Gene Information

human ... OPRM1(4988)

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General description

A certified reference standard suitable for use as a starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis, clinical toxicology, and pain prescription monitoring to urine drug testing and pharmaceutical research. Hydromorphone, marketed under brand names including Palladone and Dilaudid®, is a very potent opioid analgesic. The drug is often used medicinally as an alternative to morphine for treatment of pain or as a cough suppressant for painful coughing resulting from continued bronchial irritation.

Application


  • Quantitative analysis of Haloperidol: Development of a sensitive LC-MS/MS method for Haloperidol quantification in human plasma, employing Haloperidol-D₄ as an internal standard and incorporating phospholipid removal pretreatment to enhance detection accuracy (Zidekova et al., 2021).

  • Automated determination in toxicological studies: Utilization of Haloperidol-D₄ in an automated method for toxicokinetic studies of Trimebutine and its metabolites, demonstrating the compound′s role in high-throughput forensic toxicology (Larabi et al., 2015).

  • High-throughput drug monitoring: Application of ′high throughput′ solid-phase extraction and turbo ionspray LC-MS-MS for Haloperidol determination in plasma, showcasing the efficiency of Haloperidol-D₄ as a stable isotope-labeled standard for enhancing bioanalytical procedures (Hempenius et al., 1999).



Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dilaudid is a registered trademark of Purdue Pharma L.P.

Related product

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Popis
Stanovení ceny

H-010

Hydromorphone-D3 solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-006

Hydromorphone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

H-049

Hydromorphone-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-050

Hydromorphone-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-051

Hydromorphone-3-β-D-glucuronide, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

N-107

Norhydromorphone hydrochloride solution, 1.0 mg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant®

H-004S

Hydromorphone solution, 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Osvědčení o analýze (COA)

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Navštívit knihovnu dokumentů

Jessica R Barker et al.
Veterinary surgery : VS, 42(1), 79-84 (2012-12-12)
To evaluate efficacy of a topical epidural analgesia used alone, or in combination with hydromorphone, against a standard pain protocol for the 48 hours immediately after hemilaminectomy. Randomized, blinded, controlled, clinical trial. Dogs (n = 30) with thoracolumbar intervertebral disc disease
Bonnie L Hay Kraus
Veterinary anaesthesia and analgesia, 40(1), 28-34 (2012-10-23)
The goal of this study was to evaluate the effectiveness of maropitant (Cerenia(®)) in preventing vomiting after premedication with hydromorphone. Randomized, blinded, prospective clinical study. Eighteen dogs ASA I/II admitted for elective orthopedic surgical procedures. The dogs were a mixed
Brandon A Van Noord et al.
Journal of clinical anesthesia, 25(2), 146-149 (2013-01-22)
A 35 year old woman, 6 days after ileal neobladder construction, reported uncontrolled pain despite 33 mg hydromorphone via patient-controlled analgesia (PCA). Abdominal compartment syndrome was suspected based on worsening tachypnea, oxygen desaturation, and severe, prolonged ileus. Following emergent intubation
Martin E Hale et al.
Journal of opioid management, 8(5), 299-314 (2012-12-19)
This analysis was designed to assess the pooled safety and tolerability of once-daily hydromorphone extended release (ER) (OROS® hydromorphone ER) in opioid-naïve and opioid-tolerant patients with chronic cancer or noncancer pain. Safety results were pooled from 13 controlled and uncontrolled
Alec B O'Connor et al.
Journal of opioid management, 8(6), 403-413 (2012-12-25)
The reasons providers choose one parenteral opioid over another are not well understood. The authors sought to determine why emergency department (ED) providers choose one parenteral opioid over another. In a cohort of ED patients who received intravenous morphine or
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