902527

Amino-PEG5-t-butyl ester

≥95%

• Synonyma: tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate, H₂N-PEG₅-CH₂CH₂COOtBu
• Empirický vzorec (Hillův zápis): C₁₇H₃₅NO₇
• Číslo CAS: 1446282-18-3
• Molekulová hmotnost: 365.46
• MDL number: MFCD25424125
• UNSPSC Code: 51171641

Vlastnosti

• assay: ≥95%
• form: liquid
• reaction suitability: reagent type: cross-linking reagent
• refractive index: n/D 1.4534
• density: 1.4690 g/mL
• functional group: amine; ester
• storage temp.: −20°C
• SMILES string: NCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

Popis

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Bezpečnostní informace

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: No data available
• flash_point_c: No data available