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P-080

Supelco

Phenazepam solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C15H10N2OBrCl
CAS Number:
51753-57-2
Molecular Weight:
349.61
EC Number:
200-835-2
MDL number:
MFCD00423674
UNSPSC Code:
41116107
PubChem Substance ID:
329820057
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

Clc1ccccc1C2=NCC(=O)Nc3ccc(Br)cc23

InChI

1S/C15H10BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)

InChI key

CGMJQQJSWIRRRL-UHFFFAOYSA-N

General description

Phenazepam, a benzodiazepine drug produced in Russia, is used in Europe as an anxiolytic, anticonvulsant, and muscle relaxant. Although not used therapeutically in the US, the drug can be purchased on the internet for “laboratory research” purposes. Cases of abuse have been reported from European countries such as Sweden and Russia to states including New York, Kentucky, North Carolina, and Georgia.

Application


  • Advancements in Designer Benzodiazepine Detection: Phenazepam is included in studies aiming to advance the detection of designer benzodiazepines, contributing significantly to forensic and clinical toxicology (Wu and Fu, 2022).

  • Neuroactive Substance Monitoring: Phenazepam′s detection trends were studied in the context of new psychoactive substance monitoring, reflecting its ongoing surveillance and public health implications in Australia (Syrjanen et al., 2023).

  • Pharmacological Analysis of GABA(A) Receptors: A comprehensive pharmacological analysis was conducted on Phenazepam among other ligands, investigating its anxiolytic, anticonvulsant, and hypnotic properties through GABA(A) receptor modulation (Voronin et al., 2023).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Muta. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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G G Neznamov et al.
Eksperimental'naia i klinicheskaia farmakologiia, 74(5), 6-12 (2011-08-04)
Differences between phenazepam formulations were found in the clinical study of drug effects on the psychophysiological state in patients with anxiety disorder. Phenazepam did not cause negative changes of psychophysiological parameters. In patients with anxiety disorders, the most significant positive
L I Larentsova et al.
Bulletin of experimental biology and medicine, 148(2), 340-342 (2009-12-23)
The use of tenoten and tenoten (pediatric formulation) for premedication in adults and children before dental treatment reduces patient anxiety; the effect is comparable with that of classical anxiolytics and is not accompanied by side effects. These preparations can be
Patrick B Kyle et al.
Journal of analytical toxicology, 36(3), 207-209 (2012-03-16)
Phenazepam is a long acting benzodiazepine that is not controlled in Canada, the United States or many European countries. The abuse of phenazepam has gained recent attention due to the number of hospitalizations and fatalities resulting from overdose. The compound
G G Neznamov et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(3 Pt 1), 50-56 (2012-06-09)
The spectral-coherence analysis of phenazepam single-dose action in patients with anxiety disorder was performed. Significant changes in coherence parameters indicating the generalized character of reorganizations of interzonal connections with the involvement of delta, alpha, theta and beta-1 to beta-3 rhythms
Phenazepam is currently being misused in the UK.
Peter D Maskell et al.
BMJ (Clinical research ed.), 343, d4207-d4207 (2011-07-07)
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