1711268

Venlafaxine hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: (+/-)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride, Effexor
• Fórmula empírica (notación de Hill): C₁₇H₂₇NO₂ · HCl
• Número de CAS: 99300-78-4
• Peso molecular: 313.86
• Número MDL: MFCD03658865
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329751491
• NACRES: NA.24

Propiedades

• grado: pharmaceutical primary standard
• familia API: venlafaxine
• fabricante / nombre comercial: USP
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• cadena SMILES: Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2
• InChI: 1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
• Clave InChI: QYRYFNHXARDNFZ-UHFFFAOYSA-N
• Información sobre el gen: human ... SLC6A2(6530) , SLC6A4(6532)

Descripción

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Venlafaxine hydrochloride USP reference standard intended for use in specified quality tests and assays.

Also used to prepare standard, system suitability, and standard stock solution for assay, impurity analysis, and performance test according to the given below monographs of United States Pharmacopeia (USP):

• Venlafaxine Hydrochloride
• Venlafaxine Tablets
• Venlafaxine Hydrochloride Extended-Release Capsules
• Desvenlafaxine

Acciones bioquímicas o fisiológicas

Venlafaxine is a dual serotonin-noradrenaline reuptake inhibitor that displays Ki values of 82 and 2480 nM respectively. It is a general class antidepressant.

Venlafaxine is an antidepressant. The mechanism of the antidepresant action of venlafaxine in humans is associated with its potentiation of neurotransmitter activity in the CNS. Venlafaxine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitor of dopamine reuptake. Venlafaxine has no significant activity for muscarinic, histaminergic, or α-1 adrenergic receptors in vitro. Venlafaxine does not possess MAO inhibitor activity.

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS09
• Frases de peligro: H411
• Consejos de prudencia: P273 - P391 - P501
• Clasificaciones de peligro: Aquatic Chronic 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable