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Key Documents

1000420

USP

Abacavir Related Compound A

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

(1S,4R)-4-[2,6-Diamino-9H-purin-9-yl]-2-cyclopentene-1-methanol

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About This Item

Fórmula empírica (notación de Hill):
C11H14N6O
Número de CAS:
124752-25-6
Peso molecular:
246.27
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

abacavir

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C11H14N6O/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18/h1-2,5-7,18H,3-4H2,(H4,12,13,15,16)/t6-,7+/m1/s1

InChI key

ZKJUXHDSLJYKED-RQJHMYQMSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Abacavir Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Referencia del producto
Descripción
Precios

1000485

Abacavir Related Compounds Mixture, United States Pharmacopeia (USP) Reference Standard

1000496

Abacavir Stereoisomers Mixture, United States Pharmacopeia (USP) Reference Standard

1000500

Abacavir System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

1000408

Abacavir sulfate, United States Pharmacopeia (USP) Reference Standard

1000419

Abacavir sulfate racemic, United States Pharmacopeia (USP) Reference Standard

1000441

Abacavir Related Compound B, United States Pharmacopeia (USP) Reference Standard

1000452

Abacavir Related Compound C, United States Pharmacopeia (USP) Reference Standard

PHR1256

Abacavir sulfate, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001561

Abacavir sulfate, European Pharmacopoeia (EP) Reference Standard

Y0001551

Abacavir for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001552

Abacavir for peak identification, European Pharmacopoeia (EP) Reference Standard

1000437

Abacavir Related Compound D, United States Pharmacopeia (USP) Reference Standard

BP1112

Abacavir sulfate, British Pharmacopoeia (BP) Reference Standard

BP1113

Abacavir impurity standard, British Pharmacopoeia (BP) Reference Standard

BP1114

Abacavir Impurity 1, British Pharmacopoeia (BP) Reference Standard

PHR2074

Abacavir Impurity F, pharmaceutical secondary standard, certified reference material

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Y Wen et al.
Drug metabolism and disposition: the biological fate of chemicals, 27(1), 113-121 (1999-01-12)
Several in vitro and in situ approaches were used to determine the dominant presystemic activation site for (-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine (6AC) conversion in rats. The in vitro disappearance half-lives (mean +/- S.D.) in the cytosolic fractions obtained from homogenates
R L Yeager et al.
Drug metabolism and disposition: the biological fate of chemicals, 19(2), 462-466 (1991-03-01)
The potential for the metabolic conversion of (-)-6-aminocarbovir to (-)-carbovir, a potent reverse transcriptase inhibitor effective against human immunodeficiency virus, has been examined in male Sprague-Dawley rats. Plasma (-)-6-aminocarbovir concentrations declined rapidly in a biphasic manner following an iv bolus
C L Zimmerman et al.
Drug metabolism and disposition: the biological fate of chemicals, 28(6), 672-679 (2000-05-23)
A CBV [(-)-carbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxyguanosine] prodrug, 6AC [(-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine], was previously evaluated in rats, and it exhibited superiority to the parent drug in increasing systemic and central nervous system exposure to CBV. The gut wall was determined
Y D Wen et al.
Pharmaceutical research, 12(6), 911-915 (1995-06-01)
Evaluate the ability of (-)-6-aminocarbovir ((-)-6AC) to improve the CNS exposure to (-)-carbovir ((-)-CBV). Activation of (-)-6AC in vitro was assessed by incubations of rat brain tissue homogenates. The in vivo brain exposure to (-)-CBV was then examined in rats
Evaluation of gastrointestinal absorption and metabolism.
C L Zimmerman et al.
Drug metabolism reviews, 29(4), 957-975 (1998-01-09)
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HPLC de moléculas pequeñas

Las moléculas pequeñas son iones y compuestos de peso molecular normalmente inferior a 900 dalton. Estos compuestos pueden separarse y analizarse con eficacia mediante HPLC, UHPLC y LC-MS utilizando principalmente partículas de sílice o fases estacionarias monolíticas con una amplia gama de composiciones químicas de la columna (modificaciones).

Small Molecule HPLC

Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).

Small Molecule HPLC

Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).

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