We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.
T4382
Apo-transferrina human
powder, ≥98% (agarose gel electrophoresis)
Sinónimos:
Siderofilina, Transferrina humana
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About This Item
Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.75
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origen biológico
human
Nivel de calidad
Ensayo
≥98% (agarose gel electrophoresis)
Formulario
powder
mol peso
76-81 kDa
contenido de hierro
≤0.005%
técnicas
cell culture | mammalian: suitable
impurezas
HIV and HBsAg, source material tested negative
solubilidad
H2O: 50 mg/mL
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... TF(7018)
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Descripción general
Apo-transferrin human is a glycoprotein, possessing homologous carboxyl and amino domain. Both the domain binds to one molecule of iron.[1][2] Only 30% of transferrin is saturated with iron in the amino domain.[2] Apo-transferrin in human is encoded by the gene TF which is localized on human chromosome 3q22.1.[1]
Aplicación
Apo-Transferrin human has been used:
- to determine the competitive binding of bismuth to albumin and transferrin by fast performance liquid chromatography (FPLC)[2]
- to study titanium-transferrin complex by electrochemical method[3]
- in the preparation of transferrin solution and in the formation of conjugates with ruthenium-complexes for cellular viability studies[4]
Acciones bioquímicas o fisiológicas
Apo-transferrin is an iron transport protein. The concentration of transferrin in blood plasma is about 35 μM. Transferrin also functions in the transport of therapeutic, diagnostic and toxic ions like Ga3+, Ru3+ and Al3+.[2] Polymorphism in TF gene has pathological implications in Parkinson′s disease.[1]
Apo-transferrin is required for the survival and differentiation of oligodendroglial cells. [5]
Otras notas
Proteína transportadora de hierro no hemo.
Ligadura / enlace
Similar to T 2252
Cláusula de descargo de responsabilidad
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
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In the central nervous system (CNS), apotransferrin (aTf) is produced by oligodendroglial cells (OLGcs), and aTf is essential for cell survival. We previously demonstrated that a single intracranial injection of aTf in 3-day-old rats accelerates differentiation of OLGc and that
Artículos
Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.
Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.
Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.
Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.
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