This product has not been tested for cell culture. A sterile version is offered that is suitable for cell culture. The T5516 is a sterile preparation that is cell culture tested. Please review the product page for product T2877: https://www.sigmaaldrich.com/product/sigma/t2877
T2877
3,3′,5-Triyodo-L-tironina
≥95% (HPLC), powder
Sinónimos:
O-(4-Hidroxi-3-yodofenil)-3,5-diyodo-L-tirosina, Liotironina, T3
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About This Item
Fórmula empírica (notación de Hill):
C15H12I3NO4
Número de CAS:
Peso molecular:
650.97
Beilstein/REAXYS Number:
2710227
EC Number:
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.32
biological source:
synthetic (organic)
form:
powder
assay:
≥95% (HPLC)
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
biological source
synthetic (organic)
Quality Level
sterility
non-sterile
assay
≥95% (HPLC)
form
powder
optical activity
[α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
technique(s)
transfection: suitable
mp
234-238 °C (lit.)
solubility
4 M NH4OH in methanol: 5 mg/mL, clear to very slightly hazy, colorless to light yellow
shipped in
ambient
storage temp.
−20°C
SMILES string
N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
InChI
1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
InChI key
AUYYCJSJGJYCDS-LBPRGKRZSA-N
Gene Information
human ... THRA(7067) , THRB(7068)
rat ... Thra(81812) , Thrb(24831)
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Application
Biochem/physiol Actions
3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function.[3] The product also positively regulates the hepatic FGF21 expression[2] and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation. Additionally, the product facilitates the normal body growth in children and is pivotal for central nervous system maturation in foetus.
Preparation Note
3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution.
Other Notes
This product has not been tested for cell culture. A sterile version is offered that is suitable for cell culture. The T5516 is a sterile preparation that is cell culture tested. Please review the product page for product T2877
Related product
Referencia del producto
Descripción
Precios
signalword
Danger
hcodes
Hazard Classifications
STOT RE 1
target_organs
Thyroid,Cardio-vascular system,Kidney
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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W A Head et al.
Journal of animal science, 74(9), 2152-2157 (1996-09-01)
Targhee ewes (n = 22, average age 5 yr) rearing twin lambs were used to investigate serum growth hormone (GH), IGF-I, triiodothyronine (T3), thyroxine (T4), and prolactin (PRL; ewes only) concentrations associated with selection pressure for lifetime production of kilograms
Soledad Bárez-López et al.
PloS one, 14(12), e0226017-e0226017 (2019-12-07)
Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to impaired TH transport across the brain barriers.
Takahiro Nojiri et al.
Endocrine journal, 66(5), 409-422 (2019-03-01)
Graves' Disease is a representative autoimmune thyroid disease that presents with hyperthyroidism. Emerging evidence has shown the involvement of lysophosphatidic acid (LPA) and its producing enzyme, autotaxin (ATX), in the pathogenesis of various diseases; among them, the involvement of the
Andrew C Adams et al.
The Journal of biological chemistry, 285(19), 14078-14082 (2010-03-20)
Thyroid hormone has profound and diverse effects on liver metabolism. Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21). Mice treated with T3 showed a
R Bunevicius et al.
The New England journal of medicine, 340(6), 424-429 (1999-02-11)
Patients with hypothyroidism are usually treated with thyroxine (levothyroxine) only, although both thyroxine and triiodothyronine are secreted by the normal thyroid gland. Whether thyroid secretion of triiodothyronine is physiologically important is unknown. We compared the effects of thyroxine alone with
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