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T-076

Supelco

L-Thyroxine-13C6 solution

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
13C6C9H11I4NO4
Número de CAS:
720710-30-5
Peso molecular:
782.83
Número CE:
200-659-6
Código UNSPSC:
41116107
NACRES:
NA.24

grado

certified reference material

Nivel de calidad

300

Formulario

liquid

Características

(Snap-N-Spike®)

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

concentración

100 μg/mL in methanol with 0.1N NH3

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

clinical testing

Formato

single component solution

temp. de almacenamiento

−20°C

cadena SMILES

I[13C]1=[13C]([13C](I)=[13CH][13C](C[C@@H](C(O)=O)N)=[13CH]1)OC2=CC(I)=C(O)C(I)=C2

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1/i1+1,2+1,6+1,10+1,11+1,14+1

Clave InChI

XUIIKFGFIJCVMT-PDHVKVOFSA-N

Categorías relacionadas

Descripción general

This internal standard and Certified Spiking Solution® is suitable for quantitation of free and total T4 serum levels by LC-MS/MS for determination of hyper- or hypothyroidism and monitoring treatment with synthetic thyroid hormones.

L-Thyroxine-13C6 is an isotopically labeled form of the tyrosine-based thyroid hormone, thyroxine (T4). Thyroxine is secreted by the thyroid gland and is involved in different biological processes, such as growth, neurodevelopment, carbohydrate & oxygen metabolism, and protein synthesis

Aplicación

The Certified Reference Material (CRM) in solution can also be used as an internal standard as follows:
  • Combination of hollow fiber-liquid-phase microextraction (HF-LPME) based sample preparation and liquid chromatography-tandem mass spectrometric (LC-MS/MS) determination of total thyroxine in serum samples
  • Development of an LC-MS/MS method for the multi-residue analysis of melatonin, cortisol, triiodothyronine, thyroxine, and testosterone in rat serum samples following their dual liquid-liquid extraction
  • Simultaneous determination of thyroxine by an isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method from human serum samples
  • Estimation of thyroxine (T4) and triiodothyronine (T3) in rat cardiac tissue samples by a high-performance liquid chromatographic-tandem mass spectrometric (HPLC-MS/MS) method following their derivatization
  • Establishing and validating an LC-MS/MS-based method for the quantification of endogenous thyroid hormones, T4 and two of its T3 isomers, in tissue samples obtained from lamprey, following the enzymatic digestion and protein precipitation of the samples

Características y beneficios

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes,Central nervous system

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

49.5 °F

Punto de inflamabilidad (°C)

9.7 °C

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Certificados de análisis (COA)

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Artículos

Simultaneous Determination of Free T3 and Free T4 in Serum

Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.

Simultaneous Determination of Free T3 and Free T4 in Serum

Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.

Simultaneous Determination of Free T3 and Free T4 in Serum

Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.

Simultaneous Determination of Free T3 and Free T4 in Serum

Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.

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