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T0667

Sigma-Aldrich

Trimethoprim lactate salt

≥98%

Sinónimos:

5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt

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About This Item

Fórmula empírica (notación de Hill):
C14H18N4O3 · C3H6O3
Número de CAS:
23256-42-0
Peso molecular:
380.40
Número CE:
245-533-1
Número MDL:
MFCD00171722
Código UNSPSC:
51285203
ID de la sustancia en PubChem:
329826610
NACRES:
NA.85

Nivel de calidad

200

Ensayo

≥98%

Formulario

powder

condiciones de almacenamiento

(Keep container tightly closed in a dry and well-ventilated place.)

color

white

solubilidad

H2O: soluble 20 mg/mL

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Modo de acción

DNA synthesis | interferes
enzyme | inhibits

temp. de almacenamiento

2-8°C

cadena SMILES

CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)

Clave InChI

IIZVTUWSIKTFKO-UHFFFAOYSA-N

Categorías relacionadas

Descripción general

Chemical structure: pyrimidine

Aplicación

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

Acciones bioquímicas o fisiológicas

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

Otras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palabra de señalización

Danger

Frases de peligro

H301,H361d

Clasificaciones de peligro

Acute Tox. 3 Oral - Repr. 2

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000411104
0000398584
0000369285
0000411104
0000398584

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