SAB4502419
Anti-Peripherin antibody produced in rabbit
affinity isolated antibody
Sinónimos:
PERI, PRPH
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen 53 kDa
reactividad de especies
rat, human
concentración
~1 mg/mL
técnicas
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... PRPH(5630)
Categorías relacionadas
Descripción general
Anti-Peripherin antibody detects endogenous levels of total Peripherin protein.
The PRPH (peripherin) gene is mapped to human chromosome 12q13.12. This gene codes for a 57 kDa intermediate filament protein. Peripherin is predominantly expressed in the peripheral neurons.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human Peripherin.
Immunogen Range: 421-470
Immunogen Range: 421-470
Acciones bioquímicas o fisiológicas
Peripherin is known to be associated with the mechanism of organelle transport, function and positioning. It also forms an important part of the cytoskeleton. Mutation in PRPH (peripherin) is observed in amyotrophic lateral sclerosis. Peripherin participates in the elongation of motor axons. Upregulation of PRPH is noticed in neuronal injury.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
Lot/Batch Number
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Jesse McLean et al.
Journal of neurochemistry, 114(4), 1177-1192 (2010-06-11)
Peripherin is a type III intermediate filament protein that is up-regulated during neuronal injury and is a major component of pathological inclusions found within degenerating motor neurons of patients with amyotrophic lateral sclerosis (ALS). The relationship between these inclusions and
Joshua J Emrick et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(51), E12091-E12100 (2018-11-23)
Atopic dermatitis (AD) is the most common skin disease in children. It is characterized by relapsing inflammation, skin-barrier defects, and intractable itch. However, the pathophysiology of itch in AD remains enigmatic. Here, we examine the contribution of Tmem79, an orphan
Stephanie Shiers et al.
Pain, 161(11), 2494-2501 (2020-08-23)
SARS-CoV-2 has created a global crisis. COVID-19, the disease caused by the virus, is characterized by pneumonia, respiratory distress, and hypercoagulation and can be fatal. An early sign of infection is loss of smell, taste, and chemesthesis-loss of chemical sensation.
Paulo Victor Sgobbi de Souza et al.
Arquivos de neuro-psiquiatria, 73(12), 1026-1037 (2015-10-16)
Amyotrophic lateral sclerosis represents the most common neurodegenerative disease leading to upper and lower motor neuron compromise. Although the vast majority of cases are sporadic, substantial gain has been observed in the knowledge of the genetic forms of the disease
Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin.
Cogli L
Acta Neuropathologica, 125(2), 257-272 (2013)
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