Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

SAB5500103

Sigma-Aldrich

Anti-F4/80 antibody, Rabbit monoclonal

clone SP115, recombinant, expressed in proprietary host, affinity isolated antibody

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

recombinante

expressed in proprietary host

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

SP115, monoclonal

reactividad de especies

mouse (tested)

reactividad de especies (predicha por homología)

rat

técnicas

immunohistochemistry: 1:100

isotipo

IgG

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... ADGRE1(2015)

Descripción general

EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) is a human homolog of F4/80, an eosinophil-specific receptor. It is abundantly expressed on leukocytes. F4/80 is a member of the GPCR superfamily. It has N-terminal EGF (epidermal growth factor)-like domains bound to a seven-span transmembrane (7TM) moiety through a mucin-like spacer domain. This gene is located on human chromosome 19p13.
Mouse EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1) or cell surface glycoprotein F4/80 is a cell surface glycoprotein and a member of the EGF TM7 family of proteins. It shares 68% overall amino acid identity with human EGF-module-containing-mucin-like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ regulatory T cells.

Inmunógeno

Synthetic peptide derived from N-terminus of mouse F4/80 protein.

Aplicación

Anti-F4/80 antibody has been used in immunohistochemistry.

Acciones bioquímicas o fisiológicas

In liquid bone marrow cultures, F4/80/EMR1 (egf-like module containing, mucin-like, hormone receptor-like 1) acts as a maturation marker for mononuclear phagocytes. EMR1 can be used as a target molecule in the treatment of individuals suffering from squamous cell carcinoma and eosinophilic disorders.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

¿No encuentra el producto adecuado?  

Pruebe nuestro Herramienta de selección de productos.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97
Lin HH, et al.
Genomics, 67(2), 188-200 (2000)
Comparative evaluation of eosinophils in normal mucosa, dysplastic mucosa and oral squamous cell carcinoma with hematoxylin-eosin, Congo red, and EMR1 immunohistochemical staining techniques
Kargahi N, et al.
Electron Physician, 7(2), 1019-1026 (2015)
Jonghyo Hong et al.
Nutrients, 15(22) (2023-11-25)
Multiple studies have confirmed that Lactiplantibacillus plantarum has beneficial effects in respiratory diseases, including respiratory tract infections, asthma, and chronic obstructive pulmonary disease. However, the role of L. plantarum lysates in respiratory diseases is unclear. Staphylococcus aureus infects the lungs
Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer
Harris KL, et al.
Oncotarget, 7(20), 28947-28960 (2016)
The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs.
Hume DA, et al.
The Journal of Experimental Medicine, 158(5), 1522-1536 (1983)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico