S8442

SU 5416

≥98% (HPLC), powder, neuronal nitric oxide synthase inhibitor

• Sinónimos: 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one
• Fórmula empírica (notación de Hill): C₁₅H₁₄N₂O
• Número de CAS: 204005-46-9
• Peso molecular: 238.28
• Número MDL: MFCD01940922
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 24278606
• NACRES: NA.77

Propiedades

• Nombre del producto: SU 5416, ≥98% (HPLC)
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: yellow to yellow-orange
• mp: 221-222 °C
• solubilidad: DMSO: 20 mg/mL, clear (warmed); H₂O: insoluble
• temp. de almacenamiento: −20°C
• cadena SMILES: Cc1cc(C)c(C=C2C(=O)Nc3ccccc23)[nH]1
• InChI: 1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8+
• Clave InChI: WUWDLXZGHZSWQZ-XYOKQWHBSA-N
• Información sobre el gen: human ... EGFR(1956) , FLT1(2321) , IGFBP1(3484) , IL2(3558) , KDR(3791) , PDGFRB(5159) ; mouse ... Flt1(14254) , Kdr(16542)

Descripción

Descripción general

SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor. SU 5416 is known to prevent tumor growth and tumor angiogenesis. SU 5416 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity. It also acts as an agonist of aryl hydrocarbon receptor and may be an effective clinical agent for treating autoimmune diseases and transplant rejection.

Aplicación

SU 5416 has been used to treat HUVEC cells before the tube formation assay to assess its impact on the network generated from tube formation. to induce pulmonary hypertension (PH) in mice to serve as an experimental model

Acciones bioquímicas o fisiológicas

SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.¹ It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.²

SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves