P6503

Pilocarpine hydrochloride

≥99% (titration), powder, muscarinic acetylcholine receptor agonist

• Sinónimos: (3S,4R)-4,5-Dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride
• Fórmula empírica (notación de Hill): C₁₁H₁₆N₂O₂ · HCl
• Número de CAS: 54-71-7
• Peso molecular: 244.72
• Beilstein: 4034491
• Número CE: 200-212-5
• Número MDL: MFCD00012722
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277862
• NACRES: NA.77

Propiedades

• Nombre del producto: Pilocarpine hydrochloride, ≥99% (titration), powder
• Nivel de calidad: 100
• Ensayo: ≥99% (titration)
• Formulario: powder
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• color: white
• mp: 202-205 °C (lit.)
• solubilidad: H₂O: 100 mg/mL
• aplicaciones: forensics and toxicology; veterinary
• enfermedades relevantes: epilepsy
• cadena SMILES: Cl.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
• InChI: 1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
• Clave InChI: RNAICSBVACLLGM-GNAZCLTHSA-N
• Información sobre el gen: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Descripción

Aplicación

Pilocarpine hydrochloride has been used to stimulate salivary secretions in mice.[1] It has also been used to induce status epilepticus(SE) in rat.[2][3]

Acciones bioquímicas o fisiológicas

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Pilocarpine is alkaloid isolated from the shrub Pilocarpus species. It comprises imidazole ring and γ- lactone rings in its structure. It has cholinergic potential and it stimulates the parasympathetic system. Pilocarpine is also effective for treating glaucoma.[4] It stimulates ciliary muscle contraction by binding to muscarinic M3 receptors.[5] It is effective in treating corneal dryness in Sjogren′s syndrome.[6] It is a secretagogue, which improves salivary secretions in Xerostomia or a dry mouth condition in Sjogren′s syndrome patients[7] and in radiotherapy patients with head and neck carcinoma.[8]

Características y beneficios

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Precaución

Hygroscopic, light sensitive

Otras notas

Shelf life of the powder is at least five years.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300 + H330
• Consejos de prudencia: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Clasificaciones de peligro: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3