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Merck
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Key Documents

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S7448

Sigma-Aldrich

STF-62247

≥98% (HPLC), solid

Sinónimos:

N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

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About This Item

Fórmula empírica (notación de Hill):
C15H13N3S
Número de CAS:
315702-99-9
Peso molecular:
267.35
MDL number:
MFCD01121974
UNSPSC Code:
12352200
PubChem Substance ID:
329824583
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 26 mg/mL
H2O: insoluble

storage temp.

room temp

SMILES string

Cc1cccc(Nc2nc(cs2)-c3ccncc3)c1

InChI

1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)

InChI key

KATNUHQNJGNLPW-UHFFFAOYSA-N

Application

STF-62247 may be used as positive control in autophagy inducing cell signaling studies.

Biochem/physiol Actions

STF-62247 induces the formation of large vacuoles in the von Hippel-Lindau deficient renal carcinoma cells, a characteristic of autophagy.1
STF-62247 is a selective inducer of autophagy in VHL-deficient renal cell carcinoma cells.

hcodes

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

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Sandra Turcotte et al.
Autophagy, 4(7), 944-946 (2008-09-05)
Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor suppressor gene von Hippel-Lindau (VHL). We exploited the possibility of targeting VHL-deficient RCC
Tomohiro Kozako et al.
BMC cancer, 18(1), 791-791 (2018-08-08)
Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of SIRT2 using siRNA causes apoptosis
Kanchan Phadwal et al.
Autophagy, 8(4), 677-689 (2012-02-04)
Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical
Maximilian N Kinzler et al.
Scientific reports, 10(1), 687-687 (2020-01-22)
Induction of autophagy can have beneficial effects in several human diseases, e.g. cancer and neurodegenerative diseases (ND). Here, we therefore evaluated the potential of two novel autophagy-inducing compounds, i.e. STF-62247 and pimozide, to stimulate autophagy as well as autophagic cell
Nadia Bouhamdani et al.
Carcinogenesis, 41(6), 828-840 (2019-09-27)
The inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), has been identified as the earliest event in renal cell carcinoma (RCC) development. The loss of heterogeneity by chromosome 3p deletion followed by inactivating mutations on the second VHL copy
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