S2876

Spermine tetrahydrochloride

powder or crystals, NMDA agonist/antagonist

• Sinónimos: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
• Fórmula empírica (notación de Hill): C₁₀H₂₆N₄ · 4HCl
• Número de CAS: 306-67-2
• Peso molecular: 348.18
• Beilstein: 3911771
• Número CE: 206-189-8
• Número MDL: MFCD00012914
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278007
• NACRES: NA.77

Propiedades

• Nombre del producto: Spermine tetrahydrochloride, powder or crystals
• Formulario: powder or crystals
• Nivel de calidad: 200
• mp: 310-311 °C (dec.) (lit.)
• solubilidad: water, high purity: 100 mg/ml
• temp. de almacenamiento: room temp
• cadena SMILES: Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• Clave InChI: XLDKUDAXZWHPFH-UHFFFAOYSA-N
• Información sobre el gen: human ... GRIN1(2902)

Descripción

Aplicación

Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue,[1] archival tissue of salivary gland, renal and thyroid tumors[2] and red blood cells of chicken.[3]

Used to precipitate DNA from low salt aqueous buffers.

Acciones bioquímicas o fisiológicas

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Spermine, a polyamine, is derived from spermidine and is required for cell growth in eukaryotes. It acts as regulator of gene expression, inhibits DNA damage and protects the cells from damage by acting as free radical scavenger.[4][5] In proteomics studies, spermine mediates rapid crystallization of DNA-binding proteins.[6]

Nota de preparación

Spermine tetrahydrochloride yields clear, colorless to light yellow solution in water at 100 mg/ml.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319
• Consejos de prudencia: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves