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P7505

Sigma-Aldrich

Putrescine dihydrochloride

≥98% (TLC), powder

Sinónimos:

1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride

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About This Item

Fórmula lineal:
NH2(CH2)4NH2 · 2HCl
Número de CAS:
333-93-7
Peso molecular:
161.07
Beilstein:
3906680
Número CE:
206-375-9
Número MDL:
MFCD00012526
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24278650
NACRES:
NA.77

Nombre del producto

Putrescine dihydrochloride, ≥98% (TLC)

Nivel de calidad

400

Ensayo

≥98% (TLC)

Formulario

powder

mp

280 °C (dec.) (lit.)

solubilidad

H2O: soluble 100 mg/mL, clear, colorless

cadena SMILES

Cl[H].Cl[H].NCCCCN

InChI

1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H

Clave InChI

XXWCODXIQWIHQN-UHFFFAOYSA-N

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Aplicación

Putrescine dihydrochloride has been used:
  • as a bioactive amine standard in high-performance liquid chromatography (HPLC)
  • as a component of hormone mix supplemented to Dulbecco′s modified eagle medium (DMEM) to study its effects on neural stem cells
  • as a supplement in DMEM for culturing of endometrial cancer cells

Acciones bioquímicas o fisiológicas

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents.
Putrescine is an aliphatic amine and is positively charged. It acts as a precursor of spermine and plays a role in polyamine biosynthesis. Putrescine is found in several plants, animals, and bacteria. It plays a role in cell proliferation and cell growth in Escherichia coli. Putrescine is a component of agrochemicals, surfactants, pharmaceuticals, polymers, and additives.

Pictogramas

Skull and crossbonesCorrosion
GHS06,GHS05

Palabra de señalización

Danger

Frases de peligro

H302,H311,H314,H330

Clasificaciones de peligro

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

113.0 °F - closed cup

Punto de inflamabilidad (°C)

45 °C - closed cup

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCM4908
BCCL8316
BCCL3845
BCCK1424
BCCJ7144

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Ulises Gómez-Pinedo et al.
Frontiers in neurology, 8, 255-255 (2017-06-22)
Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. Determine the effect
Mito Kanatsu-Shinohara et al.
Methods in enzymology, 477, 17-36 (2010-08-12)
Spermatogonial stem cells (SSCs) in the testes are a new target for germline modification. With the development of an in vitro culture system and spermatogonial transplantation technique, SSCs can now be manipulated and used as an alternative to embryonic stem
Bangmin Liu et al.
Journal of animal science and biotechnology, 10, 69-69 (2019-09-14)
Polyamines are essential for cell growth and beneficial for intestinal maturation. To evaluate the effects of putrescine on alleviating intestinal atrophy and underlying molecular mechanisms, both in vivo feeding trial and in vitro cell culture were conducted. Weanling pigs were
Vegetables consumed in Brazilian cuisine as sources of bioactive amines
Dala-Paula B M, et al.
Food Bioscience, 40, 100856-100856 (2021)
Zhi-Gang Qian et al.
Biotechnology and bioengineering, 104(4), 651-662 (2009-08-29)
A four carbon linear chain diamine, putrescine (1,4-diaminobutane), is an important platform chemical having a wide range of applications in chemical industry. Biotechnological production of putrescine from renewable feedstock is a promising alternative to the chemical synthesis that originates from
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