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Merck
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Key Documents

RAB0204

Sigma-Aldrich

Human GDF-15 / MIC-1  ELISA Kit

for serum, plasma, cell culture supernatant and urine

Sinónimos:

GDF-15, Growth/differentiation factor 15 , MIC-1, Macrophage inhibitory cytokine 1

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma
sample type urine

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2 pg/mL
standard curve range: 1.1-800 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... GDF15(9518)

General description

Human GDF-15 / MIC-1 ELISA (enzyme-linked immunosorbent assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of a target protein in biological samples, such as serum, plasma, cell culture supernatants, urine and/or cell and tissue lysates. Growth differentiation factor-15 (GDF-15) is a cytokine for stress-response. It elevates during an inflammatory response and tissue injury. GDF-15 is also associated with cardiometabolic risk. It is localized in the adipocytes, macrophages, cardiomyocytes and vascular smooth muscle cells.

Immunogen

Recombinant Human GDF15

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human GDF-15 / MIC-1ELISA (enzyme-linked immunosorbent assay) kit has been used in the quantification of circulating macrophage inhibitory cytokine-1 (MIC-1) in venous blood samples.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Los componentes del kit también están disponibles por separado

Referencia del producto
Descripción
SDS
  • RABELADEELISA 5X Assay/Sample Diluent Buffer E (Item E2)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Insulin resistance, type 1 and type 2 diabetes, and related complications 2015
Ndisang J F, et al.
Journal of Diabetes Research (2015)
Azza Abdel Gawad Tantawy et al.
Blood cells, molecules & diseases, 53(4), 189-193 (2014-07-30)
High expression of growth differentiation factor-15 (GDF-15) contributes to pathological iron overload in thalassemia. Sickle cell syndromes are characterized by increased levels of erythropoiesis, although the primary defect involves the destruction of mature erythrocytes. To determine serum GDF-15 in 35
Xianxiang Song et al.
Experimental and therapeutic medicine, 16(6), 4803-4809 (2018-12-14)
Osteosarcoma is among the most frequently occurring bone tumors in infants and teenagers. However, despite its widespread prevalence, no effective diagnostic and prognostic biomarkers for osteosarcoma are known. Macrophage inhibitory cytokine 1 (MIC-1) has been considered a promising biological marker
Sébastien Jeay et al.
Cancer research, 78(21), 6257-6267 (2018-08-24)
Activation of p53 by inhibitors of the p53-MDM2 interaction is being pursued as a therapeutic strategy in p53 wild-type cancers. Here, we report distinct mechanisms by which the novel, potent, and selective inhibitor of the p53-MDM2 interaction HDM201 elicits therapeutic
Elevated circulating macrophage inhibitory cytokine 1 is a biological marker for the diagnosis and prognosis of osteosarcoma
Song X, et al.
Experimental and Therapeutic Medicine, 16(6), 4803-4809 (2018)
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