P9178

Prochlorperazine dimaleate salt

• Fórmula empírica (notación de Hill): C₂₀H₂₄ClN₃S · 2C₄H₄O₄
• Número de CAS: 84-02-6
• Peso molecular: 606.09
• EC Number: 201-511-3
• MDL number: MFCD00069330
• UNSPSC Code: 41116107
• PubChem Substance ID: 57654570
• NACRES: NA.77

Propiedades

• form: powder
• Quality Level: 200
• solubility: H₂O: slightly soluble 0.3 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3 mg/mL; methanol: soluble
• originator: GlaxoSmithKline
• SMILES string: OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1
• InChI: 1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
• InChI key: DSKIOWHQLUWFLG-SPIKMXEPSA-N
• Gene Information: human ... DRD2(1813)

Descripción

Biochem/physiol Actions

Prochlorperazine is an anti-nausea and neuroleptic agent. It is known to cause neuropsychiatric side effects. Prochlorperazine inhibits the action of dopamine in the central nervous system. It acts as an antiemetic drug and prevents vomiting and stimulates sleep. Prochlorperazine is useful as a tranquilizer in the treatment of schizophrenia and nonpsychotic anxiety.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist; antispasmodic

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H336,H361d,H362
• pcodes: P202 - P260 - P263 - P264 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Lact. - Repr. 2 - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves