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Key Documents

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P5084

Sigma-Aldrich

PTIO

Sinónimos:

2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide

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About This Item

Fórmula empírica (notación de Hill):
C13H17N2O2
Número de CAS:
18390-00-6
Peso molecular:
233.29
MDL number:
MFCD00059929
UNSPSC Code:
12352200
PubChem Substance ID:
329820215
NACRES:
NA.32

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

CC1(C)N([O])C(c2ccccc2)=[N+]([O-])C1(C)C

InChI

1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3

InChI key

DYUUGILMVYJEHY-UHFFFAOYSA-N

Application

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.

Biochem/physiol Actions

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIOs) derivatives react with nitric oxide (NO) to yield the corresponding imino nitroxides (PTIs) and nitrogen dioxide (NO2).
A stable radical scavenger for nitric oxide; affects NO without affecting NO synthase; has significant inhibitory activity against NO biological actions.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Ekaterina Minaeva et al.
PloS one, 12(10), e0186851-e0186851 (2017-10-20)
Truncated hemoglobins constitute a large family, present in bacteria, in archaea and in eukaryotes. However, a majority of physiological functions of these proteins remains to be elucidated. Identification and characterization of a novel role of truncated hemoglobins in the model
Luca G Mariotti et al.
International journal of radiation biology, 88(10), 751-762 (2012-06-20)
To investigate the mechanisms regulating the pathways of the bystander transmission in vitro, focusing on the radiation-perturbed signalling (via Interleukine 6, IL-6) of the irradiated cells after exposure to low doses of different radiation types. An integrated 'systems radiation biology'
Moonhee Lee et al.
Brain research, 1400, 99-111 (2011-06-07)
Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects
Christal G Coleman et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(36), 12103-12112 (2010-09-10)
Chronic intermittent hypoxia (CIH) is a concomitant of sleep apnea that produces a slowly developing chemosensory-dependent blood pressure elevation ascribed in part to NMDA receptor-dependent plasticity and reduced nitric oxide (NO) signaling in the carotid body. The hypothalamic paraventricular nucleus
Jiu-Gang Xue et al.
Journal of neurophysiology, 105(6), 2897-2906 (2011-04-08)
N-methyl-D-aspartate (NMDA) receptors (NMDARs) are implicated in synaptic plasticity and modulation of glutamatergic excitatory transmission. Effect of NMDAR activation on inhibitory GABAergic transmission remains largely unknown. Here, we report that a brief application of NMDA could induce two distinct actions
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