O4000

Oxythiamine chloride hydrochloride

≥95% (HPLC)

• Sinónimos: 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
• Fórmula empírica (notación de Hill): C₁₂H₁₆ClN₃O₂S · HCl
• Número de CAS: 614-05-1
• Peso molecular: 338.25
• Número MDL: MFCD00050656
• Código UNSPSC: 12352116
• ID de la sustancia en PubChem: 24897990
• NACRES: NA.79

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥95% (HPLC)
• Formulario: powder
• técnicas: HPLC: suitable
• color: white to off-white
• temp. de almacenamiento: −20°C
• cadena SMILES: CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-]
• InChI: 1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H
• Clave InChI: QHUYPZVMEJLSEB-UHFFFAOYSA-N

Descripción

Descripción general

Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.

Aplicación

Oxythiamine chloride hydrochloride is suitable for use:

• as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
• as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
• in the synthesis of oxythiamineH picrolonate salt

Acciones bioquímicas o fisiológicas

Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.

Oxythiamine inhibits Transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)