L4146
Leptin human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Sinónimos:
OB
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About This Item
origen biológico:
Escherichia coli
Formulario:
lyophilized powder
Ensayo:
≥97% (SDS-PAGE)
Productos recomendados
origen biológico
Escherichia coli
Nivel de calidad
recombinante
expressed in E. coli
esterilidad
sterile; 0.2 μm filtered
Ensayo
≥97% (SDS-PAGE)
Formulario
lyophilized powder
potencia
≤3.0 ng/mL ED50/EC50
mol peso
predicted mol wt ~16 kDa
impurezas
≤1.0 EU/μg endotoxin
Nº de acceso UniProt
Condiciones de envío
ambient
temp. de almacenamiento
−20°C
Información sobre el gen
human ... LEP(3952)
Descripción general
The gene LEP (leptin) is mapped to human chromosome 7q31. It is a 16kDa peptide. Leptin is released in the circulation and goes to the CNS (central nervous system). In CNS, it works by associating with leptin receptor.
Aplicación
Leptin human has been used:
- to study the effect of leptin on ACAT1 (acyl-coenzyme A:cholesterol acyltransferase 1) expression and cholesterol efflux from primary cultured human macrophages
- to study the effect of leptin on expression of IGFBP2 (insulin growth factor binding protein 2) in skeletal muscle
- to study the effect of leptin on HLA-G (human leukocyte antigen G) expression in placental trophoblasts
- to study the effect of leptin on in vitro maturation, fertilization and development of horse oocytes after ICSI (intracytoplasmic sperm injection)
Acciones bioquímicas o fisiológicas
Hormone produced primarily in adipocytes; primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight.
Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.
Human and mouse leptin share ~84% sequence identity.
Human and mouse leptin share ~84% sequence identity.
Leptin is believed to play a role in normal pregnancy development.
Mutations in LEP (leptin) are linked with type-2 diabetes. Presence of high levels of leptin in plasma is related to adiposity.
Forma física
Lyophilized from a 0.2 μm filtered solution with 0.0045 mM NaHCO3
Nota de análisis
The biological activity is measured by its ability to induce proliferation of leptin-dependent human OB-R transfected murine BAF3 cells.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Artículos
Lipid Induced Insulin Resistance
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