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Merck

H6501

Sigma-Aldrich

DL-β-Hydroxybutyric acid sodium salt

~98%, powder

Sinónimos:

(±)-3-Hydroxybutanoic acid sodium salt

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About This Item

Fórmula lineal:
C4H7O3Na
Número de CAS:
Peso molecular:
126.09
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.83
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Nombre del producto

DL-β-Hydroxybutyric acid sodium salt, ~98%

assay

~98%

Quality Level

form

powder

solubility

water: 1 g/10 mL, clear, colorless

Storage temp.

2-8°C

SMILES string

[Na].CC(O)CC(O)=O

InChI

1S/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1

Inchi Key

NBPUSGBJDWCHKC-UHFFFAOYSA-M

Application

DL-β-Hydroxybutyric acid sodium salt has been used:
  • as a standard for quantifying blood plasma and milk β-hydroxybutyric acid in Danish Jersey cows[1]
  • to investigate its anticonvulsant effects in epilepsy induced rats[2]
  • to induce hyperketonemia in Holstein dairy cows[3]

Biochem/physiol Actions

β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis.[1] It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model.[4] β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).[5]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Influence of DL-beta-hydroxybutyric acid on cell proliferation and calcium influx
Cheng S, et al.
Biomacromolecules, 6(2), 593-597 (2005)
Jianping Si et al.
Experimental and therapeutic medicine, 14(1), 765-770 (2017-07-05)
The present study aimed to investigate the anticonvulsant effects of β-hydroxybutyrate (BHB) in a kainic acid (KA)-induced rat seizure model. The concentrations of BHB and glucose were detected in the blood prior to exogenous BHB administration. Three different doses of
Gwinyai E Chibisa et al.
Journal of animal science, 98(6) (2020-05-25)
Cattle need physically effective fiber to promote rumination and maintain rumen health, but economics favor the use of low-roughage feedlot diets. The study investigated the optimum barley silage proportion in barley-based finishing diets. Apparent total-tract digestibility (4-d total fecal collection)
Jianping Si et al.
Experimental and therapeutic medicine, 20(6), 177-177 (2020-10-27)
The aim of the present study was to explore the potential anticonvulsant effects of β-hydroxybutyrate (BHB) in a kainic acid (KA)-induced rat epilepsy model. The KA-induced rat seizure model was established and BHB was administrated intraperitoneally at a dose of
Nikolaj Rittig et al.
Shock (Augusta, Ga.), 44(1), 32-35 (2015-04-22)
Endotoxin administrations are used in experimental models of inflammatory disease. Short-term endotoxin tolerance in response to repeated endotoxin exposure is well known, but the duration of endotoxin tolerance in humans remains unknown. The main purpose of this study was to

Questions

  1. Bonjour,  Une fois avoir dilué le BHB  dans l'eau, est-il possible de congeler la solution ?  Merci d'avance

    1 answer
    1. The stability of this product in solution has not been evaluated. However, product MAK041 is a B-Hydroxybutyrate assay kit. This kit includes a B-Hysroxybutyrate standard solution at a concentration of 10 mM. The kit is stored at −20°C and has a warranty of 1 year from the date of shipment. Similar stability would be expected for the H6501, provided the stock solution is of similar concentration and aliquoted to avoid repeated freeze/thaw cycles.

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