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G8173

Sigma-Aldrich

GW833972A

≥98% (HPLC), powder

Sinónimos:

2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C18H13ClF3N5O · HCl
Número de CAS:
1092502-33-4
Peso molecular:
444.24
Número MDL:
MFCD18452844
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329799976
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

control farmacológico

regulated under CDSA - not available from Sigma-Aldrich Canada

condiciones de almacenamiento

desiccated

color

off-white to light brown

solubilidad

DMSO: ≥20 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Cl.FC(F)(F)c1nc(Nc2cccc(Cl)c2)ncc1C(=O)NCc3ccncc3

InChI

1S/C18H13ClF3N5O.ClH/c19-12-2-1-3-13(8-12)26-17-25-10-14(15(27-17)18(20,21)22)16(28)24-9-11-4-6-23-7-5-11;/h1-8,10H,9H2,(H,24,28)(H,25,26,27);1H

Clave InChI

UBHSVFAUAKIVKL-UHFFFAOYSA-N

Aplicación

GW833972A, a selective CB2 cannabinoid receptor agonist, may be used separately or in comparison to other cannabinoid receptor agonist and antagonists to differentiate and characterize the CB2 cannabinoid receptor. GW833972A may be used to help verify that an observed physiological response is cannabinoid receptor CB2-dependent.

Acciones bioquímicas o fisiológicas

GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1. It is, however, 15-fold less potent than HU210 for CB2 (Ki 7.8 vs. 0.52 nM). The antitumor compound oxaliplatin induces marked hypersensitivity to cold, heat, and chemical pain stimuli (to the point where oxaliplatin therapy has to be discontinued). The hyperalgesia effect is almost completely blocked by pretreatment with GW833972A.
The compound was used to determine the role of CB2 in airway sensory nerve function.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H301,H315,H319,H335,H413

Clasificaciones de peligro

Acute Tox. 3 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
100M4622V
110M4622

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International journal of sports physiology and performance, 9(6), 945-952 (2014-03-14)
The study aimed to establish the test-retest reliability and convergent validity of PlayerLoad™ (triaxial-accelerometer data) during a standardized bout of treadmill running. Forty-four team-sport players performed 2 standardized incremental treadmill running tests (7-16 km/h) 7 d apart. Players' oxygen uptake
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