Saltar al contenido
Merck
Todas las fotos(3)

Key Documents

View All Documentation

F0881

Sigma-Aldrich

Fusidic acid sodium salt

≥98% (TLC)

Sinónimos:

Fucidin

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(3)

About This Item

Fórmula lineal:
C31H47O6Na
Número de CAS:
751-94-0
Peso molecular:
538.69
EC Number:
212-030-3
MDL number:
MFCD09054714
UNSPSC Code:
12352106
PubChem Substance ID:
24278430
NACRES:
NA.77

Quality Level

200

assay

≥98% (TLC)

solubility

H2O: soluble

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].C[C@@H]1[C@H](O)CC[C@@]2(C)C1CC[C@@]3(C)C2[C@H](O)CC4\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C([O-])=O

InChI

1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1

InChI key

HJHVQCXHVMGZNC-JCJNLNMISA-M

¿Está buscando productos similares? Visita Guía de comparación de productos

General description

Fusidic acid is an antibiotic substance, resembling the structure of a steroid. It belongs to the class of fusidanes.

Application

Fusidic acid sodium salt has been used to study the effects of three-drug combinations on the growth rate of a bacterium, wild-type Escherichia coli. It is also used to study the in vitro susceptibility of dog-derived European methicillin-resistant Staphylococcus pseudintermedius and Staphylococcus aureus strains and their methicillin-susceptible counterparts.

Biochem/physiol Actions

Fusidic acid possesses antimicrobial action against skin pathogens. It is highly specific to Staphylococcus aureus. It is therefore used for treating infected traumatic wounds, folliculitis, furunculosis, impetigo, erythrasma and abscesses.
Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Los clientes también vieron

Slide 1 of 4

1 of 4

Carbenoxolone disodium salt ≥98%

Sigma-Aldrich

C4790

Carbenoxolone disodium salt

Rifampicina ≥95% (HPLC), powder or crystals

Sigma-Aldrich

R3501

Rifampicina

Linezolid ≥98% (HPLC)

Sigma-Aldrich

PZ0014

Linezolid

Lidocaine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1034

Lidocaine

Fusidic acid in dermatology
British Journal of Dermatology, 37-40 (1998)
Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs
<BIG>Tekin E, et al.</BIG>
Journal of the Royal Society, Interface / the Royal Society, 20160332-20160332 (2016)
Susceptibility in vitro of canine methicillin-resistant and-susceptible staphylococcal isolates to fusidic acid, chlorhexidine and miconazole: opportunities for topical therapy of canine superficial pyoderma
<BIG>Clark SM, et al. </BIG>
The Journal of Antimicrobial Chemotherapy, 2048-2052 (2015)
Ravi Kiran Koripella et al.
The Journal of biological chemistry, 287(36), 30257-30267 (2012-07-07)
Antibiotic resistance in bacteria is often associated with fitness loss, which is compensated by secondary mutations. Fusidic acid (FA), an antibiotic used against pathogenic bacteria Staphylococcus aureus, locks elongation factor-G (EF-G) to the ribosome after GTP hydrolysis. To clarify the
Maria Selmer et al.
Acta crystallographica. Section D, Biological crystallography, 68(Pt 5), 578-583 (2012-04-25)
Crystallographic studies of the ribosome have provided molecular details of protein synthesis. However, the crystallization of functional complexes of ribosomes with GTPase translation factors proved to be elusive for a decade after the first ribosome structures were determined. Analysis of
Ver todos los artículos relacionados

Artículos

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico