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Key Documents

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E3638

Sigma-Aldrich

Estazolam

Sinónimos:

8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

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About This Item

Fórmula lineal:
C16H11N4Cl
Número de CAS:
29975-16-4
Peso molecular:
294.74
EC Number:
249-982-4
MDL number:
MFCD00867537
UNSPSC Code:
12352200
PubChem Substance ID:
24894524
NACRES:
NA.77

Quality Level

200

drug control

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

originator

Abbott

SMILES string

Clc1ccc-2c(c1)C(=NCc3nncn-23)c4ccccc4

InChI

1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2

InChI key

CDCHDCWJMGXXRH-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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Biochem/physiol Actions

Hypnotic; ligand for the GABAA receptor benzodiazepine modulatory site.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kirkwood, C.K., et al.
Journal of the American Pharmaceutical Association, 39, 688-688 (1999)
M Miura et al.
Xenobiotica; the fate of foreign compounds in biological systems, 35(5), 455-465 (2005-07-14)
To predict drug interactions with estazolam, the biotransformation of estazolam to its major hydoxylated metabolite, 4-hydroxyestazolam was studied in vitro using pooled human liver microsomes and individual expressed human cytochrome P450 (CYP) enzymes. Estazolam was metabolized to 4-hydroxyestazolam according to
Jiu-xi Yuan et al.
Fa yi xue za zhi, 27(2), 117-119 (2011-05-25)
To investigate the stability of estazolam in biological samples preserved in formaldehyde solution. The dog was given intragastric administration of estazolam with a dose of 37.6 mg/kg and killed 2 h later. Heart, liver, kidney and brain of the dog
Chao-Yun Xia et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 29(3), 211-215 (2009-11-10)
To evaluate the therapeutic effects and safety of the XIA's No.1 Sleeping Prescription for the treatment of insomnia of the deficiency type. 120 cases conformed to the diagnostic criteria of the Chinese Classification of Mental Disorders-Version 3 (CCMD-3) and were
Yahdiana Harahap et al.
Arzneimittel-Forschung, 58(10), 501-504 (2008-11-26)
To compare the bioavailability of two estazolam (CAS 29975-16-4) tablet formulations (Estalin 2 mg tablets as test formulation and 2 mg tablets of the originator product as reference formulation). The study was conducted according to an open label, randomized two-way
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