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D8190

Sigma-Aldrich

3′,4′-Dichlorobenzamil hydrochloride

>98% (HPLC)

Sinónimos:

L-594,881

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About This Item

Fórmula empírica (notación de Hill):
C13H12N7OCl3 · HCl
Número de CAS:
928621-15-2
Peso molecular:
425.10
MDL number:
MFCD03839362
UNSPSC Code:
12352200
PubChem Substance ID:
24278390
NACRES:
NA.77

Quality Level

100

assay

>98% (HPLC)

form

solid

color

yellow

solubility

DMSO: soluble 30 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

NC1=NC(N)=C(Cl)N=C1C(NC(NCC2=CC(Cl)=C(Cl)C=C2)=N)=O.Cl

InChI

1S/C13H12Cl3N7O.ClH/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8;/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24);1H

InChI key

LPHAOBPPRPXQLQ-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibits Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Toru Oda et al.
Journal of pharmacological sciences, 116(1), 128-131 (2011-04-28)
To elucidate the role of Na(+)/Ca(2+) exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells. KB-R7943 and 3',4'-dichlorobenzamil, NCX inhibitors, inhibited the neurite outgrowth caused by nerve growth factor (NGF). NCX
Takahiro Horinouchi et al.
European journal of pharmacology, 566(1-3), 28-33 (2007-04-21)
Endothelin ET(A) receptor couples to Gq/11 protein that transduces a variety of receptor signals to modulate diverse cellular responses including Ca2+ mobilization. Stimulation of endothelin ETA receptor with endothelin-1 is generally believed to induce an increase in intracellular Ca2+ concentration
Manu Hegde et al.
The Journal of pharmacology and experimental therapeutics, 310(1), 67-74 (2004-03-11)
Previously, we demonstrated that malignant glioma cell lines have increased intracellular pH (pHi) as a result of increased activities of the type I sodium/hydrogen exchanger (NHE1). This alkalotic pHi of 7.2 to 7.4 is favorable for augmented glycolysis, DNA synthesis
M N Sharikabad et al.
American journal of physiology. Heart and circulatory physiology, 280(1), H344-H353 (2000-12-21)
The effects of Mg(2+) on reactive oxygen species (ROS) and cell Ca(2+) during reoxygenation of hypoxic rat cardiomyocytes were studied. Oxidation of 2',7'-dichlorodihydrofluorescein (DCDHF) to dichlorofluorescein (DCF) and of dihydroethidium (DHE) to ethidium (ETH) within cells were used as markers
Friedrich Brunner et al.
Cardiovascular research, 60(2), 355-364 (2003-11-14)
The oxidant species peroxynitrite, the reaction product of nitric oxide (NO.) and superoxide, has been implicated in several pathophysiological conditions of the heart. Here, we studied the mechanism of peroxynitrite-induced cardiac depression using specific drugs and simultaneous analyses of myocardial
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