The following reference uses Dynasore at 80 μM: Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).
D7693
Dynasore monohydrate
≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor
Sinónimos:
3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide monohydrate
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About This Item
Fórmula empírica (notación de Hill):
C18H14N2O4 · xH2O
Número de CAS:
Peso molecular:
322.31 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Nombre del producto
Dynasore monohydrate,
form
powder
Quality Level
storage condition
protect from light
color
off-white
solubility
DMSO: ≥10 mg/mL
H2O: insoluble
storage temp.
−20°C
SMILES string
O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI
1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
InChI key
FKWZHQSDBMSHTN-ZIOFAICLSA-N
General description
Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization.[1] Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.[2]
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization.[1] Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.[2]
Application
Dynasore hydrate has been used:
- for priming fetal mesenchymal stem/stromal cells (fMSC)[3]
- in confocal microscopy[4]
- in wound healing/scratch and tube-formation assay[5]
- to analyse its effects on Coxsackievirus A9 (CAV9) infection[6]
- to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis[7]
- in live imaging of cells[8]
Biochem/physiol Actions
Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Artículos
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?
1 answer-
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How can I store a solution of Product D7693, Dynasore hydrate?
1 answer-
We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What can I use to make a solution of Product D7693, Dynasore hydrate?
1 answer-
As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL. It is also soluble in ethanol at 1 mg/mL.
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