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Merck

C5851

Sigma-Aldrich

CGP 35348 hydrate

≥97% (NMR), solid

Sinónimos:

(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate

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About This Item

Fórmula empírica (notación de Hill):
C8H20NO4P · xH2O
Número de CAS:
Peso molecular:
225.22 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥97% (NMR)

form

solid

storage condition

desiccated

color

white

solubility

H2O: >20 mg/mL

originator

Novartis

storage temp.

−20°C

SMILES string

O.CCOC(OCC)P(O)(=O)CCCN

InChI

1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2

InChI key

SRBHGEXMDCJOMS-UHFFFAOYSA-N

Application

CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:
  • to study its effects on intrinsic optical signal (IOS) in rat hippocampus
  • alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
  • to study its effects on hepatocellular carcinoma cells (HCC)

Biochem/physiol Actions

CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Caution

Product is hygroscopic

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Gamma-hydroxybutyrate (GHB) is used therapeutically and recreationally. The mechanism by which GHB produces its therapeutic and recreational effects is not entirely clear, although GABA(B) receptors seem to play an important role. This role could be complex, because there are indications
N G Bowery
Annual review of pharmacology and toxicology, 33, 109-147 (1993-01-01)
In conclusion, GABAB receptors appear to be of major importance in synaptic processing within the brain and are present at both post- and presynaptic sites. Their activation can hyperpolarize neurones and diminish neurotransmitter release from presynaptic terminals. We already know
Fulvia Bongianni et al.
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Interleukin-1beta (IL-1beta), a cytokine that is closely associated with inflammation and immune stress, is known to interfere with reproductive functions. Earlier studies have demonstrated that IL-1beta inhibits the luteinizing hormone (LH) surge during the afternoon of proestrus in female rats.
Chirag R Patel et al.
Frontiers in neurology, 5, 235-235 (2014-12-03)
Sodium salicylate (SS) is a widely used medication with side effects on hearing. In order to understand these side effects, we recorded sound-driven local-field potentials in a neural structure, the dorsal cortex of the inferior colliculus (ICd). Using a microiontophoretic

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