17772

Retinol

≥95.0% (HPLC), ~2700 U/mg

• Sinónimos: Alcohol de vitamina A, Axerophthol, Vitamina A, Vitamina A₁, todo-trans-3,7-Dimetil-9-(2,6,6-trimetil-1-ciclohexen-1-il)-2,4,6,8-nonatetraen-1-ol
• Fórmula empírica (notación de Hill): C₂₀H₃₀O
• Número de CAS: 68-26-8
• Peso molecular: 286.45
• Beilstein: 403040
• Número CE: 200-683-7
• Número MDL: MFCD00001552
• Código UNSPSC: 12352205
• eCl@ss: 34058018
• ID de la sustancia en PubChem: 329751561
• NACRES: NA.79

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 100
• Ensayo: ≥95.0% (HPLC)
• Formulario: (Powder or Crystal with Lumps)
• actividad específica: ~2700 U/mg
• color: yellow to dark yellow
• mp: 61-63 °C (lit.)
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/CO)=C(C)CCC1
• InChI: 1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
• Clave InChI: FPIPGXGPPPQFEQ-OVSJKPMPSA-N

Descripción

Descripción general

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinol is biologically active in a wide range of processes.

Retinol or all-trans-retinol is a 20-carbon molecule with cyclohexenyl ring, a side chain with four double bonds (all in trans configuration) and an alcohol end group.

Aplicación

Retinol has been used as a standard in ultra-performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) for the vitamins detection and quantification.

Acciones bioquímicas o fisiológicas

Retinol and its derivatives exhibit anti-aging properties. Retinol is used for treating wrinkles and signs of aging. However, due to its photo instability and skin irritation potency, it is hardly used in cosmetic formulations. Retinol is also used as a therapeutic for dermatoses. Its deficiency leads to xerosis and follicular hyperkeratosis.

Definición de unidad

1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H317,H319,H360FD,H413
• Consejos de prudencia: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Clasificaciones de peligro: Aquatic Chronic 4 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 1
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves