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06627

Sigma-Aldrich

2-Aminoacridone

BioReagent, suitable for fluorescence, ≥98.0% (HPLC)

Sinónimos:

2-Amino-9(10H)-acridinone, 2-amino-10H-acridin-9-one, AMAC

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About This Item

Fórmula empírica (notación de Hill):
C13H10N2O
Número de CAS:
27918-14-5
Peso molecular:
210.23
Beilstein:
172520
Número MDL:
MFCD00037397
Código UNSPSC:
12352108
ID de la sustancia en PubChem:
329748253
NACRES:
NA.32

Línea del producto

BioReagent

Nivel de calidad

100

Ensayo

≥98.0% (HPLC)

solubilidad

DMF: soluble
DMSO: soluble

fluorescencia

λex 420 nm; λem 542 nm in 0.1 M Tris pH 8.0

idoneidad

suitable for fluorescence

cadena SMILES

Nc1ccc2Nc3ccccc3C(=O)c2c1
Nc1ccc2Nc3ccccc3C(=O)c2c1

InChI

1S/C13H10N2O/c14-8-5-6-12-10(7-8)13(16)9-3-1-2-4-11(9)15-12/h1-7H,14H2,(H,15,16)

Clave InChI

PIGCSKVALLVWKU-UHFFFAOYSA-N

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Aplicación

2-Aminoacridone is a highly fluorescent aromatic, which contains a primary amine group that reacts with an aldehyde group at the reducing end of a carbohydrate and is reduced to a stable amine derivative by sodium borohydride (NaBH4). Picomolar levels of glycan compounds can be detected using this fluorophore. The resulting derivatzed compounds can be separated by reverse-phase HPLC and detected by positive-ion electrospray MS . An intense fluorescent, hydrophobic probe that is stable over a wide pH range is useful in the derivatization of glycans to allow for the analysis of complex oligosaccharides using micellar electrokinetic capillary chromatography and reverse- and normal-phase chromatography coupled with mass spectroscopy to determine relative concentrations and structural identity of individual oligosaccharides . The λ excitation and λ emission are 425 nm and 532 nm, respectively.
Fluorescent label for glycans and saccharides.
Fluorescent label for glycans and saccharides. The analysis of fluorophore-labeled glycans by high-resolution polyacrylamide gel electrophoresis.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCL0545
BCCK4182
BCCJ0661
BCCH8544
BCCG3801

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Vojtech Franc et al.
Journal of the American Society for Mass Spectrometry, 29(6), 1099-1110 (2018-03-14)
The human complement hetero-trimeric C8αβγ (C8) protein assembly (~ 150 kDa) is an important component of the membrane attack complex (MAC). C8 initiates membrane penetration and coordinates MAC pore formation. Here, we charted in detail the structural micro-heterogeneity within C8, purified from
Yong Zhang et al.
Electrophoresis, 28(3), 414-421 (2007-03-16)
To improve the separation of monosulfate glycosaminoglycan disaccharide isomers by microchip electrophoresis, we found that addition of 1,4-dioxane (DO) dramatically improved analyte resolution, probably due to solvation effects. Methylcellulose (MC) was tested for the ability to suppress EOF and analyte
Nicola Volpi
Analytical biochemistry, 397(1), 12-23 (2009-09-23)
In this study, we developed an on-line reverse-phase high-performance liquid chromatography-electrospray ionization-mass spectrometry (RP-HPLC-ESI-MS) separation and structural characterization of hyaluronan (HA)/chondroitin sulfate (CS)/dermatan sulfate (DS) disaccharides released by enzymatic treatment and derivatized with 2-aminoacridone (AMAC), providing a high-resolution system also
Martin Giera et al.
The Analyst, 136(13), 2763-2769 (2011-05-26)
Malondialdehyde (MDA) has become a well-established biomarker for oxidative stress. The most commonly used way to determine urinary MDA levels is the thiobarbituric acid (TBA) assay, which suffers from several drawbacks. In this manuscript, we describe a novel derivatization strategy
Alicia M Hitchcock et al.
Electrophoresis, 29(22), 4538-4548 (2008-11-28)
This work describes improved workup and instrumental conditions to enable robust, sensitive glycosaminoglycan (GAG) disaccharide analysis from complex biological samples. In the process of applying CE with LIF to GAG disaccharide analysis in biological samples, we have made improvements to
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