B5887

Sodium butyrate

≥98.5% (GC)

• Sinónimos: Butyric acid sodium salt
• Fórmula lineal: CH₃CH₂CH₂COONa
• Número de CAS: 156-54-7
• Peso molecular: 110.09
• Beilstein/REAXYS Number: 3629439
• EC Number: 205-857-6
• MDL number: MFCD00002816
• UNSPSC Code: 12352107
• PubChem Substance ID: 24891873
• NACRES: NA.25

Propiedades

• biological source: synthetic (organic)
• Quality Level: 200
• assay: ≥98.5% (GC)
• form: powder
• storage condition: (Tightly closed. Dry.; Keep in a dry place. )
• technique(s): DNA amplification: suitable; cell based assay: suitable; inhibition assay: suitable
• color: white
• mp: 250-253 °C (lit.)
• solubility: water: 100 mg/mL, clear to slightly hazy, colorless
• cation traces: Na: 19.8-22.0% (anhydrous)
• suitability: suitable for DNA precipitation
• application(s): cell analysis; life science and biopharma; lipidomics
• storage temp.: room temp
• SMILES string: [Na+].CCCC([O-])=O
• InChI: 1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
• InChI key: MFBOGIVSZKQAPD-UHFFFAOYSA-M
• Gene Information: mouse ... ENSMUSG00000061062(15181)

Descripción

Application

Sodium butyrate has been used:

• as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
• as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
• to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Biochem/physiol Actions

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca²⁺ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Caution

Hygroscopic

Other Notes

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Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves