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Key Documents

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B5274

Supelco

Bupivacaine hydrochloride monohydrate

analytical standard, for drug analysis

Sinónimos:

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

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About This Item

Fórmula empírica (notación de Hill):
C18H28N2O · HCl · H2O
Número de CAS:
73360-54-0
Peso molecular:
342.90
EC Number:
241-917-8
MDL number:
MFCD00941462
UNSPSC Code:
41116107
PubChem Substance ID:
329773253
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

100

assay

≥99%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

O.Cl.CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C

InChI

1S/C18H28N2O.ClH.H2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H;1H2

InChI key

HUCIWBPMHXGLFM-UHFFFAOYSA-N

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Categorías relacionadas

Application

Bupivacaine hydrochloride monohydrate may be used as an analytical standard for the determination of the bupivacaine in pharmaceutical preparations and plasma samples using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Sodium channel blocker, local anesthetic.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
BCBZ5207
BCBW8645
BCBM7058V
BCBQ9309V
BCBQ9309

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Determination of free concentration of ropivacaine and bupivacaine in blood plasma by ultrafiltration and coupled-column liquid chromatography
Arvidsson T and Eklund E
Journal of Chromatography. B, Biomedical Sciences and Applications, 668(1), 91-98 (1995)
Arnaud Chaumeron et al.
Clinical orthopaedics and related research, 471(7), 2284-2295 (2013-03-22)
The postoperative analgesic potential of periarticular anesthetic infiltration (PAI) after TKA is unclear as are the complications of continuous femoral nerve block on quadriceps function. We asked (1) whether PAI provides equal or improved postoperative pain control in comparison to
De Q H Tran et al.
Anesthesia and analgesia, 116(5), 1170-1175 (2013-03-16)
In this prospective, randomized, observer-blinded trial, we compared ultrasound-guided subparaneural popliteal sciatic nerve blocks performed either at or proximal to the neural bifurcation (B). We hypothesized that the total anesthesia-related time (sum of performance and onset times) would be decreased
Huiyuan Zhang et al.
Drug design, development and therapy, 13, 1659-1666 (2019-06-14)
Background: Bupivacaine (Bup) is the most commonly used local anesthetic. However, Bup induces cytotoxicity, especially in older patients. Recent reports have indicated that andrographolide (Andro) exhibits protective effects on human neurons. Nevertheless, whether Andro can inhibit Bup-induced cytotoxicity remains unclear.
Kejian Shi et al.
Anesthesia and analgesia, 116(4), 804-809 (2013-03-06)
While lipid emulsion may reverse the systemic toxicity of bupivacaine, the pharmacokinetics and tissue distribution of bupivacaine after lipid emulsion infusion are not clear. In this study, we assessed the influence of lipid emulsion administration on the pharmacokinetics and tissue
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