22632

Quinine hydrochloride dihydrate

tested according to Ph. Eur.

• Sinónimos: Chinini hydrochloridum, (8α, 9R)-6′-Methoxycinchonan-9-ol monohydrochloride dihydrate
• Fórmula empírica (notación de Hill): C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• Número de CAS: 6119-47-7
• Peso molecular: 396.91
• Beilstein/REAXYS Number: 6112655
• EC Number: 205-001-1
• MDL number: MFCD00151248
• UNSPSC Code: 12352210
• PubChem Substance ID: 329752329
• NACRES: NA.25

Propiedades

• agency: USP/NF; tested according to Ph. Eur.
• Quality Level: 100
• form: solid
• solubility: water: soluble 0.25 mg in 5 ml
• application(s): pharmaceutical (small molecule)
• SMILES string: O.O.Cl.COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
• InChI: 1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1
• InChI key: MPQKYZPYCSTMEI-FLZPLBAKSA-N

Descripción

Application

Quinine hydrochloride dehydrate has been used for fluorescent in situ detection of quinine in cinchona bark using UV resonance raman spectroscopy. It has also been used as a actinometric system to measure the light-induced changes in ruthenium anticancer agent, NAMI-A.

Biochem/physiol Actions

Quinine is a very effective anti-malarial treatment but is considered toxic for routine treatment due to the development of drug resistance in the malarial parasites. It acts as blood schizonticide.Quinine reportedly blocks the membrane conductance of potassium in enteric neurons.

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H317,H334
• pcodes: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves